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CNS Involvement in Chronic Inflammatory Demyelinating Polyneuropathy: A Visual Evoked Potential Study | OMICS International | Abstract
ISSN: 2155-9562

Journal of Neurology & Neurophysiology
Open Access

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Research Article

CNS Involvement in Chronic Inflammatory Demyelinating Polyneuropathy: A Visual Evoked Potential Study

Masanaka Takeda1*, Hisao Tachibana2, Kenkichi Tuda1, Sayoko Wada1, Syuhei Kasama1, Shohei Watanabe1, Toshio Takaoka1, Takashi Kimura1, Koji Kajiyama1 and Hiroo Yoshikawa1

1Neurology and Stroke Unit, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan

2Division of General Medicine, Department of Internal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan

Corresponding Author:
Masanaka Takeda
Neurology and Stroke Unit, Hyogo College of Medicine
1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan
Tel: +81-798-6598
Fax: +81-798-6597
E-mail: [email protected]

Received date: November 03, 2010; Accepted date: November 20, 2010; Published date: November 22, 2010

Citation: Takeda M, Tachibana H, Tuda K, Wada S, Kasama S, et al. (2010) CNS Involvement in Chronic Inflammatory Demyelinating Polyneuropathy: A Visual Evoked Potential Study. J Neurol Neurophysiol 1:105. doi:10.4172/2155-9562.1000105

Copyright: © 2010 Takeda M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The visual evoked potentials (VEPs) of 10 patients with chronic inflammatory demyelinating polyneuropathy (CIDP) and 25 normal subjects were studied to identify possible evidence of central nervous system (CNS) demyelination. VEPs were performed in each patient before and 1 month after treatment with intravenous immunoglobulins (IVIg). Prolonged P100 latency (≥mean±2SD of normal subjects) in 3 patients (30%) in at least one eye before IVIg treatment was improved in both eye stimulations after treatment. They also showed recovery of motor function after IVIg administration. MRI showed no lesions suggestive of CNS demyelination in any patients. Our findings suggest the existence of combined central and peripheral demyelinating lesions in CIDP and emphasize the possibility of a common pathogenic mechanism for both lesions.

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