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Coexistence of Systemic Lupus Erythematosus and Primary Biliary Cirrhosis | OMICS International | Abstract
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
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Review Article

Coexistence of Systemic Lupus Erythematosus and Primary Biliary Cirrhosis

Toru Shizuma*
Department of Physiology, School of Medicine, Tokai University, Japan
Corresponding Author : Toru Shizuma
Department of Physiology, School of Medicine
Tokai University, 143, Shimokasuya, Isehara, Kanagawa, 259-1193, Japan
Tel: +81-0463-93-1121
Fax: +81-0463-93-6684
E-mail: [email protected]
Received: March 03, 2014; Accepted: April 15, 2014; Published: April 22, 2014
Citation: Shizuma T (2014) Coexistence of Systemic Lupus Erythematosus and Primary Biliary Cirrhosis. J Clin Cell Immunol 5:211. doi:10.4172/2155-9899.1000211
Copyright: © 2014 Shizuma T. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Although autoimmune diseases often coexist, cases of concomitant systemic lupus erythematosus (SLE) and primary biliary cirrhosis (PBC) are rare. In this paper, 20 cases of concomitant SLE and PBC in the English and Japanese literature were reviewed and summarized. In concomitant cases of SLE and PBC, PBC was diagnosed first in 68.4% (13/19) of the cases and SLE occurred first in 31.6% (6/19) of the cases, although one case was suspected to have simultaneous onset. There may be no correlation between SLE activity and PBC development. In 20 reported cases of concomitant SLE and PBC, two elderly patients died because of liver failure as a result of worsening PBC, and hepatocellular carcinoma was detected in only one elderly patient.