alexa Coexistent Sarcoidosis and Alopecia Areata or Vitiligo:
ISSN: 2155-9554

Journal of Clinical & Experimental Dermatology Research
Open Access

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Case Report

Coexistent Sarcoidosis and Alopecia Areata or Vitiligo: A Case Series and Review of the Literature

Laura Melnick1, Karolyn A Wanat2, Roberto Novoa3, John Harris4, George Cotsarelis5 and Misha Rosenbach5*

1Children’s Hospital of Philadelphia, Philadelphia, PA, USA

2Department of Dermatology, University of Iowa, Iowa City, IA, USA

3Department of Dermatopathology, University of Pennsylvania, Philadelphia, PA, USA

4Department of Medicine, Division of Dermatology, University of Massachusetts Medical School, Worcester, MA, USA

5Department of Dermatology, University of Pennsylvania, Philadelphia, PA, USA

*Corresponding Author:
Misha Rosenbach
Department of Dermatology
Hospital of the University of Pennsylvania
Perelman School of Medicine, 2 Maloney Building
3600 Spruce St, Philadelphia, PA 19104, USA
Tel: 215-662-2737
Fax: 215-662- 7774
E-mail: [email protected]

Received date: August 26, 2014; Accepted date: September 22, 2014; Published date: September 29, 2014

Citation: Melnick L, Wanat KA, Novoa R, Harris J, Cotsarelis G, et al. (2014) Coexistent Sarcoidosis and Alopecia Areata or Vitiligo: A Case Series and Review of the Literature. J Clin Exp Dermatol Res 5:236. doi:10.4172/2155-9554.1000236

Copyright: © 2014 Melnick L, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

 

Abstract

Importance: Sarcoidosis is a multi-system inflammatory disease that frequently affects the lungs, lymph nodes, eyes and skin. The immunopathogenesis underlying sarcoidosis continues to be an area of active research. The presence of other diseases, such as vitiligo or alopecia, in individuals with sarcoidosis proposes a potential overlap in the immunological and inflammatory pathways of these diseases. Observations: We present 4 patients with sarcoidosis and coexistent alopecia or vitiligo. Patients 1 and 2 had subcutaneous sarcoidosis and pulmonary sarcoidosis, respectively, and presented with alopecia areata. Patient 3 had a history of alopecia universalis and presented with cutaneous sarcoidosis. Lastly, patient 4 had a history of cutaneous sarcoidosis and presented with vitiligo. Conclusions and relevance: The presence of prominent Th1 and possible Th17 inflammatory profiles in sarcoidosis, alopecia and vitiligo suggests a possible overlap in the immunological and inflammatory pathways of these diseases. Given the relatively rare combination of these diseases, large scale databases and genetic linkage studies are necessary to further explore the immunopathophysiology underlying these diseases and eventually lead to new therapeutic advances.

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