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ISSN: 2161-1068

Mycobacterial Diseases
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Case Report

Co-Infection with M. tuberculosis and M. leprae-Case Report and Systematic Review

Srinivas Rajagopala1*, Uma Devaraj2, George D’Souza3 and Vijay V Aithal4

1Division of Chest diseases, Department of Medicine, St John’s Medical College Hospital, India

2Division of Chest diseases, Department of Medicine, St John’s Medical College Hospital, India

3Division of Chest diseases, Department of Medicine, St John’s Medical College Hospital, India

4Department of Dermatology, St John’s Medical College Hospital, India

Corresponding Author:
Srinivas Rajagopala
Assistant Professor, Division of Chest diseases
Department of Medicine, St John’s Medical College Hospital
Sarjapur Road, Bangalore, India-560034
Tel: +91 80 22065353
Fax: +91 80 25501144
E-mail: [email protected]

Received Date: May 25, 2012; Accepted Date: June 14, 2012; Published Date: June 16, 2012

Citation: Rajagopala S, Devaraj U, D’Souza G, V Aithal V (2012) Co-Infection with M. tuberculosis and M. leprae-Case Report and Systematic Review. J Mycobac Dis 2:118. doi:10.4172/2161-1068.1000118

Copyright: © 2012 Rajagopala S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: Co-infection with Mycobacterium tuberculosis and M. leprae is infrequent and conflicting views on their interaction exist.

Methods: We describe an immunocompetent male with simultaneously diagnosed primary multi-drug resistant extra-pulmonary tuberculosis and borderline lepromatous leprosy; we also review all cases of dual infection reported in English literature

Results: Our search yielded 156 cases of dual infections. Most dual infections were reported in middle-aged males. The sentinel infection was leprosy in 90.4%. Most affected patients had lepromatous leprosy (52.5%) but tuberculosis occurred throughout the disease spectrum of leprosy. The time to development of the second infection varied from 1 month-25 years (median 1.5 years). Tuberculosis was reported to occur in 2.5-13.5% of cases in six series of patients with lepromatous leprosy. Most patients were diagnosed by sputum smears and radiography. Comorbid conditions predisposed to development of tuberculosis in most patients. The most common pre-disposing factor was malnutrition (92.5%). Dual infections were associated with high mortality (37.2%) and morbidity (5.3%)

Conclusions: Dual mycobacterial infections occur despite partial cross-immunity between both species. Directly observed treatment for tuberculosis with intensive medical monitoring is required to prevent poor outcomes during management of these complex patients

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