alexa Cold Storage Exacerbates Renal and Mitochondrial Dysfunction Following Transplantation
ISSN: 2472-1220

Journal of Kidney
Open Access

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Short Communication

Cold Storage Exacerbates Renal and Mitochondrial Dysfunction Following Transplantation

Shrum S, MacMillan-Crow LA and Parajuli N*

Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, USA

*Corresponding Author:
Nirmala Parajuli
Ph.D., University of Arkansas for Medical Sciences
325 Jack Stephens Drive, Biomedical Bldg. I 333
Little Rock, AR 72205, USA
Tel: 501-686-5290
Fax: 501-686-8970
E-mail: [email protected] edu

Received Date: December 04, 2015; Accepted Date: January 27, 2016; Published Date: February 27, 2016

Citation: Shrum S, MacMillan-Crow LA, Parajuli N (2016) Cold Storage Exacerbates Renal and Mitochondrial Dysfunction Following Transplantation. J Kidney 2:114. doi:10.4172/2472-1220.1000114

Copyright: © 2016 Shrum S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Long-term renal function is compromised in patients receiving deceased donor kidneys which require cold storage exposure prior to transplantation. It is well established that extended cold storage induces renal damage and several labs, including our own, have demonstrated renal mitochondrial damage after cold storage alone. However, to our knowledge, few studies have assessed renal and mitochondrial function after transplantation of rat kidneys exposed to short-term (4 hr) cold storage compared to transplant without cold storage (autotransplantation). Our data reveal that cold storage plus transplantation exacerbated renal and mitochondrial dysfunction when compared to autotransplantation alone.


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