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Collapsing Glomerulopathy in Transplanted Kidneys: Only a Tip of the Iceberg? | OMICS International | Abstract
ISSN: 2161-0991

Journal of Transplantation Technologies & Research
Open Access

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Collapsing Glomerulopathy in Transplanted Kidneys: Only a Tip of the Iceberg?

Muhammed Mubarak*

Associate professor, Histopathology Department, Sindh Institute of Urology and Transplantation, Karachi-74200, Pakistan

*Corresponding Author:
Muhammed Mubarak
Associate professor, Histopathology Department
Sindh Institute of Urology and Transplantation
Karachi-74200, Pakistan
Tel: 009221 9215752
Fax: 009221 2726165
Email: [email protected]

Received Date: July 14, 2011; Accepted Date: July 20, 2011; Published Date: September 26, 2011

Citation: Mubarak M (2011) Collapsing Glomerulopathy in Transplanted Kidneys: Only a Tip of the Iceberg? J Transplant Technol Res 1: 105e. doi: 10.4172/2161-0991.1000105e

Copyright: © 2011 Mubarak M. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Renal transplantation is the treatment of choice for patients with end-stage renal disease (ESRD) from a variety of causes. Although the short term results of renal transplantation have improved remarkably during the recent past, the long term outcomes have not improved to the same extent [1]. The long term success is marred by the occurrence of gradual onset of the often irreversible graft parenchymal scarring process, previously called as chronic allograft nephropathy (CAN), and now replaced by the term interstitial fibrosis/tubular atrophy (IF/TA) by the Banff group [2]. The later complication is multifactorial in origin and is the final common pathway resulting from both immune and non-immune mechanisms of graft injury [1,2]. Among the non-immune causes, the occurrence of recurrent or de novo renal diseases, especially the glomerulopathies, is of particular concern, as the frequency of this complication tends to rise with increasing post transplantation duration and is one of the major causes of IF/TA in the long run.

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