alexa Colon Cancer and Immunotherapy: CD40 Ligand as a Potent
ISSN: 1747-0862

Journal of Molecular and Genetic Medicine
Open Access

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Colon Cancer and Immunotherapy: CD40 Ligand as a Potential Therapeutic Target

Orfanos S1, Patelis N1*, Davakis S1, Vailas M1, Damaskos C2, Margonis GA3, Pikoulis E1 and Antoniou E2

1First Department of Surgery, Laiko General Hospital, National and Kapodistrian University of Athens, Athens, Greece

2Department of Propaedeutic Surgery, Laiko General Hospital, School of Medicine, University of Athens, Athens, Greece

3Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore

*Corresponding Author:
Dr. Nikolaos Patelis
First Department of Surgery
Laiko General Hospital
National and Kapodistrian University of Athens
Athens, Greece
Tel: 302107456243
E-mail: [email protected]

Received Date: February 23, 2017 Accepted Date: March 14, 2017 Published Date: March 17, 2017

Citation: Orfanos S, Patelis N, Davakis S, Vailas M, Damaskos C, et al. (2017) Colon Cancer and Immunotherapy: CD40 Ligand as a Potential Therapeutic Target. J Mol Genet Med 11: 253 doi:10.4172/1747-0862.1000253

Copyright: © 2017 Orfanos S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

 

Abstract

CD40, a member of the tumor necrosis factor (TNF) superfamily, it is broadly expressed on a variety of cells. There are studies to suggest that the expression of CD40 is correlated to several malignancies, while its innate therapeutic qualities are yet to be confirmed. Colon cancer is one of the most common cancers, while little can be done for the patients with advance colon cancer even at the presence time. CD40 are present in the colon cancer, and are a possible therapeutic immunotherapy target in order to enhance the overall survival rates of the patients with advanced disease.

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