Colour Vision Defect in Patients with High-Tension Glaucoma
|Andrea Saifrtová1, Jan Lešták1,2,3*, Jaroslav TintÄra1, Zuzana Svatá1, Lukáš Ettler1, Pavel Rozsíval3 and Zuzana Veselá-Florová1|
|1JL Clinic, V HÅ¯rkách 1296/10, Praha, Czech Republic|
|2Czech Technical University in Prague, Faculty of Biomedical Engineering, Czech Republic|
|3Charles University Faculty of Medicine in Hradec Králové, Czech Republic|
|Corresponding Author :||Jan Lestak, MD, PhD
JL Clinic, V Hurkach 1296/10
158 00 Prague 5, Czech Republic
E-mail: [email protected]
|Received March 27, 2012; Accepted November 06, 2012; Published November 12, 2012|
|Citation: Saifrtová A, Lešták J, Tintera J, Svatá Z, Ettler L, et al. (2012) Colour Vision Defect in Patients with High-Tension Glaucoma. J Clin Exp Ophthalmol 3:252. doi:10.4172/2155-9570.1000252|
|Copyright: © 2012 Saifrtová A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
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Objective: To prove potential difference between black/white and yellow/blue stimulation when using functional magnetic resonance imaging (fMRI) examination in advanced stages of glaucoma disease.
Methods and materials: The authors examined eight patients with various stages of high-tension glaucoma using functional magnetic resonance imaging (fMRI). The group was compared to a group of eight healthy persons. Measurements were performed on the Philips Achieva 3T TX MR system using the BOLD method. Optical stimulation was provided by black/white and yellow/blue checkered patterns alternated with their negatives with a frequency of 2 Hz. Each measurement consisted of a sequence with five 30-second periods of active phase and five resting periods of the same length. The obtained data were processed by SPM8 software and GLM. The difference in the number of activated voxels when using the black/white or yellow/blue stimulations was tested by a t-test. Statistical maps of BW>YB and BW<YB differences for patients and controls were thresholded at the uncorrected threshold of p=0.001 and the number of voxels statistically compared by a t-test.
Results: The mean value of the difference in the number of activated voxels when using the BW vs. YB stimulation was 59% for the patients while for the controls it was only 2%. While the BW>YB difference between the control group and the patients differed by the statistically significant 1606 voxels (p=0.039), no difference was found for BW<YB (p=0.18).
Conclusion:The authors showed that in the advanced stages of the glaucoma disease functional changes occurred in the cerebral cortex. The colour vision defect in the patients with high tension glaucoma was more significant than the authors had expected.