alexa Combination of Cold Atmospheric Plasma and Vitamin C Ef
ISSN: 2327-5073

Clinical Microbiology: Open Access
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Short Communication

Combination of Cold Atmospheric Plasma and Vitamin C Effectively Disrupts Bacterial Biofilms

Santosh Pandit1, Mokkapati VRSS1, Saga Huld Helgadóttir2, Fredrik Westerlund1 and Ivan Mijakovic1,3*

1Department of Biology and Biological Engineering, Chalmers University of Technology, Kemivägen 10, SE 412 96, Gothenburg, Sweden

2Department of Physics, University of Gothenburg, SE-412 96 Göteborg, Sweden

3Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Anger Englundsvej 1, DK 2800 Lyngby, Denmark

*Corresponding Author:
Mijakovic I
Department of Biology and Biological Engineering
Chalmers University of Technology
Kemivägen 10, SE 412 96, Gothenburg, Sweden
Tel: +46-70-982-84-46
E-mail: [email protected]

Received date: June 12, 2017; Accepted date: June 27, 2017; Published date: June 30, 2017

Citation: Pandit S, Mokkapati VRSS, Helgadóttir SH, Westerlundan F, Mijakovic I (2017) Combination of Cold Atmospheric Plasma and Vitamin C Effectively Disrupts Bacterial Biofilms. Clin Microbiol 6:283. doi: 10.4172/2327-5073.1000283

Copyright: © 2017 Santosh Pandit, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Cold atmospheric plasma (CAP) is increasingly used in medical applications for eradication of bacterial and tumor cells. CAP treatment devices, known as plasma jet pens, produce reactive oxygen and nitrogen species at atmospheric pressure and room temperature. The produced reactive species are concentrated in a small and precisely defined area, allowing for high precision medical treatments. CAP has been demonstrated as very effective against planktonic bacterial cells. Unfortunately, bacterial cells in biofilms are typically aggregated and protected by dense exopolymeric matrix, synthesized and secreted by the bacterial community. The main limitation in using CAP against bacterial biofilms is the thick protective matrix of extracellular polymers that shields bacterial cells within this complex architecture. CAP has also been shown to effectively eradicate tumor cells, but the main current limitation is the susceptibility of the surrounding healthy tissues to higher doses. We have recently demonstrated that vitamin C, a natural food supplement, can be used to destabilize bacterial biofilms and render them more susceptible to the CAP killing treatment. Here we discuss the possible impact that a pre-treatment with vitamin C could have on CAP applications in medicine. Specifically, we argue that vitamin C could enhance the effectiveness of CAP treatments against both the bacterial biofilms and some selected tumors.


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