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Combination of Pulmonary Rehabilitation and Neuromuscular Electrical Stimulation in COPD Patients: A Randomized Clinical Trial of Efficacy | OMICS International | Abstract
ISSN: 2161-105X

Journal of Pulmonary & Respiratory Medicine
Open Access

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Research Article

Combination of Pulmonary Rehabilitation and Neuromuscular Electrical Stimulation in COPD Patients: A Randomized Clinical Trial of Efficacy

Ercole Zanotti*, Catiuscia Bizzarri, Roberta Grasso and Claudio Fracchia

Department of Pulmonary Rehabilitation, Fondazione S. Maugeri IRCCS, Scientific Institute of Montescano, 27040 Montescano (PV), Italy

*Corresponding Author:
Dr. Ercole Zanotti
Department of Pulmonary Rehabilitation
Fondazione S. Maugeri IRCCS
Scientific Institute of Montescano
27040 Montescano (PV) Italy
Tel: 393-8524-7324
Fax: 393-8524-7321
E-mail: john. [email protected]

Received date: November 10, 2011; Accepted date: January 15, 2012; Published date: January 15, 2012

Citation: Zanotti E, Bizzarri C, Grasso R, Fracchia C (2012) Combination of Pulmonary Rehabilitation and Neuromuscular Electrical Stimulation in COPD Patients: A Randomized Clinical Trial of Efficacy. J Pulmonar Respirat Med 2:112. doi:10.4172/2161-105X.1000112

Copyright: © 2012 Zanotti E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Aims:Effectiveness of combination of pulmonary rehabilitation (PR) and neuromuscular electrical stimulation (NMPR) in severe chronic obstructive pulmonary disease (COPD) is well established. We verified the effects of NMPR compared with pulmonary rehabilitation and sham stimulation (SSPR) in patients with moderately impaired COPD.

Methods:Quadriceps strength (sit-to-stand test: STST) and exercise capacity (6 minute walking test: 6MWT) were considered primary outcomes. Lung function, dyspnoea (modified Medical Research Council: mMRC) and quality of life (St. George’s Respiratory Questionnaire: SGRQ) secondary outcomes.

Results:83 stable patients in stage II, moderate COPD (23 female; mean age, 61.7 ± 9.1 years; FEV1 59.8 ± 7.3% of predicted) were enrolled. Quadriceps strength was enhanced by SSPR (STST + 7±1.7 repetitions; p≤0.001); NMPR further increased strength (+10±1.6 repetitions; p≤0.001) with a significant difference (p≤0.05) between the treatments. SSPR significantly increased exercise capacity (6MWD + 85.3±11.5 m; p=0.01); NMPR further increased the distance walked (6MWD +146.4±32.7 m; p=0.01) with a significant difference (p≤0.05) between the treatments. None of the two treatments influenced lung function. Quality of life score (SGRQ – 8.3±2.1; p=0.01) and dyspnoea score (mMRC-0.7±0.18; p=0.01) decreased after SSPR suggesting a positive effect. NMPR did not further improve the score.

Conclusions:This study confirms that PR is able to ameliorate quadriceps strength, exercise capacity, quality of life and dyspnoea in moderately impaired COPD patients. NMPR may further improve quadriceps strength and exercise capacity with respect to PR alone.

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