alexa Combined Fecal Transferrin Test and Immuno Fecal Occult Blood Test for Detecting Colorectal Cancer and Advanced Adenoma in Asymptomatic and Symptomatic Populations
ISSN: 1948-5956

Journal of Cancer Science & Therapy
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Research Article

Combined Fecal Transferrin Test and Immuno Fecal Occult Blood Test for Detecting Colorectal Cancer and Advanced Adenoma in Asymptomatic and Symptomatic Populations

Peng Jin1,2, Jian-qiu Sheng1*, Zi-tao Wu1, Ming-ming Meng1, Xin Wang1, Xiao-wei Wang1, Li-juan Gong1, Dong-liang Yu1, Hui Xie1, Ai-qin Li1, Shi-rong Li1, Lawrence Yen3 and Jianyu Rao3*

1Department of Gastroenterology, Beijing Military General Hospital, Beijing, People’s Republic of China

2Postgraduate School, Third Military Medical University, Chongqing, People’s Republic of China

3Department of Pathology and Laboratory Medicine, David Geffen School of Medicine and Department of Epidemiology, School of Public Health, University of California, Los Angeles, California, USA

*Corresponding Author:
Jian-qiu Sheng
Department of Gastroenterology
Beijing Military General Hospital
Nanmenchang 5#, Dongcheng District
Beijing, China, 100700
E-mail: [email protected]
Jianyu Rao
Department of Pathology and Laboratory Medicine
David Geffen School of Medicine, and Department of Epidemiology
School of Public Health
University of California
Los Angeles, CA, USA
Tel: 310-794-1567
Fax: 310-825-7795
E-mail: [email protected]

Received Date: July 30, 2012; Accepted Date: August 06, 2012; Published Date: August 08, 2012

Citation: Jin P, Wu ZT, Meng MM, Wang X, Wang XW, et al. (2012) Combined Fecal Transferrin Test and Immuno Fecal Occult Blood Test for Detecting Colorectal Cancer and Advanced Adenoma in Asymptomatic and Symptomatic Populations. J Cancer Sci Ther 4:243-248. doi: 10.4172/1948-5956.1000149

Copyright: © 2012 Jin P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Recent proteomic studies identified Transferin (TF) as a potential colon cancer biomarker. A dipstick TF test similar to Immuno Fecal Occult Blood Test (IFOBT) was developed, and an initial study showed the TF test had compatible performance characteristics for detecting colon cancer and adenoma. The goal of this study was to evaluate the efficacy of the combination of TF and IFOBT for detecting advanced adenomas and cancer in asymptomatic and symptomatic populations. A total of 1,943 healthy subjects (asymptomatic group) and 201 subjects with various gastrointestinal symptoms (symptomatic group) were recruited for the study. For asymptomatic subjects, one fecal sample was collected for concurrent TF and IFOBT testing. Colonoscopy was performed for individuals positive for either TF or IFOBT. For the symptomatic subjects, each individual underwent TF, IFOBT, and colonoscopy simultaneously. For asymptomatic group, 1,737 individuals tested for TF and IFOBT, 251 subjects (14.5%) showed either TF or IFOBT positivity. Colonoscopy was performed for 193 of the 251 individuals. A total of 3 colorectal cancers and 43 advanced adenomas were detected. Combination of the two tests (either/or) significantly increased the detection rate for colorectal cancers and advanced adenomas compared to IFOBT alone (2.6% vs. 1.6%, P=0.034). In the symptomatic group, the combined test also significantly increased the sensitivity for detecting advanced adenomas and cancer than that of IFOBT alone (77.9% vs. 55.9%, P=0.006), but with decreased specificity (42.1% vs 63.9%, P=0.005). Combined TF and IFOBT test increased the detection rate of colorectal adenoma and cancer in both asymptomatic and symptomatic populations.

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