alexa Combined REDV Polypeptide and Heparin onto Titanium Sur
ISSN: 2157-7013

Journal of Cell Science & Therapy
Open Access

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Research Article

Combined REDV Polypeptide and Heparin onto Titanium Surface for the Hemocompatibility and Selectively Endothelialization

Kun Zhang1,2,3, Jing-an Li3*, Jian Wang3, Tao Liu3, Xue Wang3, Jun-ying Chen3, Nan Huang3 and Fang-xia Guan1,2

1Center of Stem Cell and Regenerative Medicine, First Affiliated Hospital of Zhengzhou University, 40 University Road, Zhengzhou 450052, PR China

2School of Life Science, Zhengzhou University, 100 Science Road, Zhengzhou 450001, PR China

3Key Laboratory for Advanced Technologies of Materials, Ministry of Education, School of Material Science and Engineering, Southwest Jiaotong University, Chengdu 610031, PR China

*Corresponding Author:
Jing-an Li
Key Laboratory for Advanced Technologies of Materials
Ministry of Education
School of Material Science and Engineering
Southwest Jiaotong University
Chengdu 610031, PR China
Tel: +86-13551284797
Fax: +86-28-87600625
E-mail: [email protected]

Received Date: January 30, 2015; Accepted Date: February 26, 2015; Published Date: February 28, 2015

Citation: Zhang K, Li J, Wang J, Liu T, Wang X, et al. (2015) Combined REDV Polypeptide and Heparin onto Titanium Surface for the Hemocompatibility and Selectively Endothelialization. J Cell Sci Ther 6:198. doi: 10.4172/2157-7013.1000198

Copyright: © 2015 Zhang K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



To enhance the blood compatibility and selective endothelialization of the cardiovascular implants simultaneously, in this study, the mixture of REDV polypeptide and heparin was used to modify titanium (Ti) surfaces in virtue of a polylysine layer. Blood compatibility tests revealed that the modified Ti prolonged blood coagulation time compared with Ti surface. Endothelial cells (ECs)/platelets and ECs/smooth muscle cells (SMCs) competed seeding results showed more attached ECs on the modified samples than that on Ti surfaces. Thus, in vitro evaluation indicates that the REDV polypeptide and heparin modified Ti surface kept excellent biocompatibility, which could improve the blood compatibility and selectively promotes the endothelialization simultaneously. We conceive that the cooperation of REDV polypeptide and heparin may provide a promising selection for biomaterials surface modification of vascular implants.

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