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Comet Assay on Toxicogenetics; Several Studies in Recent Years on Several Genotoxicological Agents | OMICS International | Abstract
ISSN: 2161-0525

Journal of Environmental & Analytical Toxicology
Open Access

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Review Article

Comet Assay on Toxicogenetics; Several Studies in Recent Years on Several Genotoxicological Agents

Tarek Gharsalli*

Faculty of Pharmacy of Monastir, Tunisia

*Corresponding Author:
Tarek Gharsalli
Faculty of Pharmacy of Monastir, Tunisia
Tel: + 21697070320
Email: [email protected]

Received Date: November 02, 2016; Accepted Date: November 16, 2016; Published Date: November 21, 2016

Citation: Gharsalli T (2016) Comet Assay on Toxicogenetics; Several Studies in Recent Years on Several Genotoxicological Agents. J Environ Anal Toxicol 6:418. doi: 10.4172/2161-0525.1000418

Copyright: © 2016 Gharsalli T. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Cancer is one of the main causes of death in the world. Prolonged exposure to genotoxic chemicals observed is one of the primary causes of cancer. A number of assays exist for detection of genotoxicity in a variety of experimental systems. The Comet assay also known as the single cell gel electrophoresis assay is used to detect DNA damage as an indicator of exposure to geno toxicogical agents. The Comet assay is a broadly used method in human, environmental, and eco genotoxicological studies. The aim of our review is to describe Comet Assay protocol with the advantages and limits and to develop some recent studies in which the authors have used comet test to confirm or reverse agent’s genotoxicity.

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