Comment-Protein Contact Networks: A New Framework for Structural Biology
|Luisa Di Paola*|
|Campus Bio-Medico di Roma University, via Alvaro del Portillo 21, 00128 Rome, Italy|
|Corresponding Author :||Luisa Di Paola
Faculty of Engineering
Campus Bio-Medico di Roma University
via Alvaro del Portillo 21, 00128 Rome, Italy
E-mail: [email protected]
|Received August 26, 2014; Accepted August 28, 2014; Published August 30, 2014|
|Citation: Di Paola L (2014) Comment-Protein Contact Networks: A New Framework for Structural Biology. J Phys Chem Biophys 4:e120. doi:10.4172/2161-0398.1000e120|
|Copyright: © 2014 Di Paola L. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
Protein structure information is not sufficient to predict biological functionality. Among different approach of analysis, protein contact networks provide a previliged point of view through the recognition of proteins as complex networks: the invariant of the networks are related to different properties of protein molecules.
Folding dynamics and allosteric binding find new and detailed description within this framework, pointing at this methodology as one of the most promising in the perspective of big data analysis of whole proteomes.