alexa Comparative Analysis of Serum Lipid Profile between Normotensive and Hypertensive Pakistani Pregnant Women | OMICS International | Abstract
ISSN: 1747-0862

Journal of Molecular and Genetic Medicine
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Research Article

Comparative Analysis of Serum Lipid Profile between Normotensive and Hypertensive Pakistani Pregnant Women

Rabia Anjum1, Nureen Zahra1, Kanwal Rehman2, Rabail Alam1, Asia Parveen1, Muhammad Tariq3 and Muhammad Sajid Hamid Akash2,4*

1Institute of Molecular Biology and Biotechnology, The University of Lahore, Lahore, Pakistan

2Institute of Pharmacology, Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University Hangzhou, China

3Department of Pharmacy, The University of Lahore, Lahore, Pakistan

4College of Pharmacy, Government College University Faisalabad, Faisalabad, Pakistan

Corresponding Author:
Muhammad Sajid Hamid Akash
Institute of Pharmacology, Toxicology and Biochemical Pharmaceutics
College of Pharmaceutical Sciences, Zhejiang University Hangzhou
China and College of Pharmacy
Government College University Faisalabad, Faisalabad, Pakistan
E-mail: [email protected]

Received date: July 11, 2013; Accepted date: August 06, 2013; Published date: August 08, 2013

Citation: Anjum R, Zahra N, Rehman K, Alam R, Parveen A, et al. (2013) Comparative Analysis of Serum Lipid Profile between Normotensive and Hypertensive Pakistani Pregnant Women. J Mol Genet Med 7:64. doi:10.4172/1747-0862.1000064

Copyright: © 2013 Anjum R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Pregnancy-induced hypertension (PIH) is one of a major cause of maternal mortality. Serum lipid profile plays pivotal role in the regulation of normal blood pressure during pregnancy. The aim of our study was to evaluate the alteration of serum lipid profile during normotensive and hypertensive pregnancy. This case-control study was conducted among the pregnant women visiting Jinnah Hospital Lahore, Pakistan from September, 2012 to March, 2013. Total 200 participants were evaluated out of which 50 were normotensive pregnant women (28 ± 8 years) taken as a normal control group and 150 were enrolled as hypertensive (30 ± 6 years) study group. Average blood pressure for normotensive pregnant women was 115/75 whereas, for hypertensive pregnant women it was 148.45/95.40. The levels of different serum lipids were measured using respective analytical kits. Hypertension was directly associated with increased levels of serum TGs (161.02 ± 3.58 vs. 105.31 ± 8.53), TC (188.90 ± 4.11 vs. 152.45 ± 1.99), LDL (136.50 ± 3.17 vs. 70.48 ± 2.14) and VLDL (117.06 ± 1.05 vs. 41.06 ± 1.70), and fall in HDL (49.41 ± 1.56 vs. 37.16 ± 1.64) as compared to that of normotensive pregnant women. The increased levels of TGs, TC, and LDL in hypertensive pregnant women were also correlated with significantly increased values of TC/HDL, TGs/HDL and LDL/HDL in hypertensive pregnant women. From the results of our study, it can be concluded that lipid profile plays their critical role in regulating blood pressure during pregnancy. Increased levels of TC, TGs, LDL and VLDL induced hypertension, whereas, HDL regulated the blood pressure to normal levels. This association may be significant in understanding the development of hypertension during pregnancy and may help in developing the strategies for prevention and treatment of PIH.

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