alexa Comparative Analysis of Vaginal Bacterial Diversity in Northern-Chinese Women Associated With or Without Bacterial Vaginosis
ISSN: 2161-0703

Journal of Medical Microbiology & Diagnosis
Open Access

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Research Article

Comparative Analysis of Vaginal Bacterial Diversity in Northern-Chinese Women Associated With or Without Bacterial Vaginosis

Yajuan Liu1#, Wenbo Hao1#, Chaohui Duan2#, Jianping Tan3, Weiwen Xu1, Shimeng Zhang1, Xiaoqing Liao1, Ming Li1 and Shuhong Luo1*

1Institute of Antibody Engineering, School of Biotechnology, Southern Medical University, 1838 N. Guangzhou Avenue, Guangzhou People’s Republic of China

2Laboratory of Clinical Immunology, the Sun Yat-Sen Memorial hospital, Sun Yat-Sen University, Guangzhou People’s Republic of China

3Department of obstetrics and gynecology, the Sun Yat-Sen Memorial hospital, Sun Yat-Sen University, Guangzhou People’s Republic of China

#These authors contributed equally to this work.

*Corresponding Author:
Dr. Shuhong Luo
Institute of Antibody Engineering, School of Biotechnology
Southern Medical University, Guangzhou Avenue
Guangzhou, Guangdong Province, China
Tel: 8620-61648325
Fax : 8620- 61648554
E-mail: [email protected]

Received date: March 17, 2012 Accepted date: May 22, 2012 Published date: May 30, 2012

Citation: Liu Y, Hao W, Duan C, Tan J, Xu W, et al. (2012) Comparative Analysis of Vaginal Bacterial Diversity in Northern-Chinese Women Associated With or Without Bacterial Vaginosis. J Medical Microbiol Diagnosis S5:001. doi:10.4172/2161-0703.S5-001

Copyright: © 2012 Liu Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



 Background: Bacterial Vaginosis (BV) is the common vaginal infection in women and it has been linked to enhanced risks for pre-term birth, pelvic inflammatory disease and sexually transmitted diseases. BV is caused by a disorder of vaginal microbiota which changes from the normal lactobacillus dominated community to a more diverse community of non-lactobacillus bacteria. Several previous reports analyzed the overall vaginal microbial communities of volunteers from limited sampling area and they suggested a possible link between the vaginal microbial contents and the ethnicity of women. Here, we analyzed the diversity of vaginal microbiota in 10 subjects associated with BV (BV+) and 10 subjects without BV (BV-) from the metropolitan area of Herbing in Northern China using full-length 16S rDNA. Results: The vaginal bacterial communities detected in subjects with BV were much more taxon rich and diverse than those without BV. At a 97% sequence similarity cutoff, the number of operational taxonomic units (OTUs) per 10 subjects with BV was nearly three times greater than 10 subjects without BV by 29.4 ± 9.3 versus 11.7 ± 7.8 (Mean ±SD). Our data confirmed that there is a shift in the abundance of bacterial species present in the vaginal environment when BV and non-BV groups were compared. Each sequence read was assigned to a genus or a species when possible. Principal component analysis was performed at genus levels. Most BV+ samples clustered together while there were two clusters among BV- samples. Several bacteria have been found to be associated with BV, including Gardnerella, Atopobium, Peptoniphilus, Leptotrichia/Sneathia, Prevotella, Parvimonas and Dialister, Based on result of classification, four possible novel phylotype microorganisms were found.   Conclusions: The data presented here on the composition and richness of the vaginal microbial ecosystem in BV and health state will provide the depth insight in the etiology of BV.

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