Comparative Anti-Proliferative Studies of Natural Phenolic Monoterpenoids on Human Malignant Tumour CellsJamatsing D Rajput, Suresh D Bagul, Samina Tadavi and Ratnamala S Bendre*
School of Chemical Sciences, North Maharashtra University, Jalgaon, Maharashtra, India
- *Corresponding Author:
- Ratnamala S Bendre
School of Chemical Sciences
North Maharashtra University
Jalgaon, Maharashtra, India
E-mail: [email protected]
Received Date: February 07, 2016; Accepted Date: December 16, 2016; Published Date: December 20, 2016
Citation: Rajput JD, Bagul SD, Tadavi S, Bendre RS (2016) Comparative Anti- Proliferative Studies of Natural Phenolic Monoterpenoids on Human Malignant Tumour Cells. Med Aromat Plants (Los Angel) 5:279. doi: 10.4172/2167- 0412.1000279
Copyright: © 2016 Rajput JD, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
In present study we report prominent effect of carvacrol (5-isopropyl-2-methyl phenol), thymol (2-isopropyl-5- methyl phenol) and eugenol (4 allyl-2-methoxyphenol) on Human melanoma cells. These three compounds were screened for Anti-proliferative test by using Sulforhodamine B (SRB) assay. For this investigation we used human breast melanoma cell line MCF-7, human skin melanoma cell line SK-MEL-2, human colon melanoma cell line HCT-15 and human pancreatic melanoma cell line MIAPaCa-2. Carvacrol was identified as most potent molecule with low GI50 value as 0.1 μL for selected human cancer cell lines; which is comparatively equal to standard drug 14 Adriamycin (ADR). Thymol and Eugenol also exhibited remarkable GI50 for human cancer cell 15 lines.