alexa Comparative Effectiveness of Cyanoacrylate Bioadhesives
ISSN: 2157-7099

Journal of Cytology & Histology
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Comparative Effectiveness of Cyanoacrylate Bioadhesives and Monofilament Suture in Wound Healing: A Histopathological and Physicochemical Study in New Zealand White Rabbit

Angulo A1*, Sebastián I2, Martínez FJ2, Torregrosa R3, Martín-Martínez JM3 and Madariaga AM2

 

1Optics, Pharmacology and Anatomy Department, University of Alicante, 03080 Alicante, Spain

2Animal House Facilities, Research Technical Services, University of Alicante, 03080 Alicante, Spain

3Adhesion and Adhesives Laboratory, University of Alicante, 03080 Alicante, Spain

*Corresponding Author:
Angulo A
Optics, Pharmacology and Anatomy Department, University of Alicante
03080 Alicante, Spain
Tel: +61424220219
E-mail: [email protected]

Received Date:December 15, 2015; Accepted Date: January 25, 2016; Published Date: January 27, 2016.

Citation: Angulo A, Sebastián I, Martínez FJ, Torregrosa R, Martín-Martínez JM, et al. (2016) Comparative Effectiveness of Cyanoacrylate Bioadhesives and Monofilament Suture in Wound Healing: A Histopathological and Physicochemical Study in New Zealand White Rabbit. J Cytol Histol 7:395. doi:10.4172/2157-7099.1000395

Copyright: © 2016 Angulo A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Comparative performance of suture and cyanoacrylate adhesives of different alkyl chain length for wound healing were compared in-vivo in New Zealand White rabbits. The alkyl chain length of the cyanoacrylate adhesive determines its effectiveness in tissue repair. The n-butyl cyanoacrylate (BCN) adhesive is very aggressive on the rabbit skin due to high exothermal reaction whereas wound closures with ethyl cyanoacrylate (ECN) and n-octyl cyanoacrylate (OCN) are adequate and similar. No significant alterations were found in the standard biochemical and haematological parameters test. When ECN and OCN adhesives are used, the wounds close with little inflammation, the edges are not separated and the tissues throughout the joined areas and nearby are normal. However, due to BCN stiffness, closed wounds show opened edges and intense inflammation. ECN and OCN adhesives present advantages vs. suture, i.e. less time for application, good confrontation of both sides of the incision, immediate haemostasis, less inflammation and absence of infection.

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