alexa Comparative Effectiveness Research: Are The Methods Being Used Correctly?
ISSN: 2471-268X

Health Economics & Outcome Research: Open Access
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Research Article

Comparative Effectiveness Research: Are The Methods Being Used Correctly?

Paula Andrade*, Tatiana Dilla and José A Sacristán

Medical Department, Lilly, Avenida de la Industria, Madrid, Spain

*Corresponding Author:
Paula Andrade
Health Outcomes Scientist
Medical Department
Lilly, Avenida de la Industria, 30, 28108 Alcobendas
Madrid, Spain
Tel: +34 91 623 33 16
Fax: +34 91 663 52 31
E-mail: [email protected]

Received Date: June 02, 2017; Accepted Date: June 19, 2017; Published Date: June 26, 2017

Citation: Andrade P, Dilla T, Sacristán JA (2017) Comparative Effectiveness Research: Are The Methods Being Used Correctly?. Health Econ Outcome Res 3:132.doi: 10.4172/2471-268X.1000132

Copyright: © 2017 Andrade P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Rationale, aims and objectives: Comparative Effectiveness Research (CER) seeks to identify what health care interventions work best for improving health at both the individual and population level. The objective of this study was to determine whether published comparative effectiveness research studies adhere to accepted methodological principles.

Methods: Structured literature search of CER articles published in high-impact general medicine journals between 2009 and 2015, and assessment of their adherence to five methodological principles.

Results: 93 articles were retrieved from the search and 40 articles were finally selected. All of the studies included active comparators, 35% of the studies did not evaluate safety, 97% did not evaluate costs, 95% of the studies did not included patient perspectives, and 60% did not use any procedure to determine the heterogeneity of the response.

Conclusion: The sample of CER papers examined did not meet the recommended requisites for this type of studies. Our findings suggest that the majority of CER studies may not be useful to guide physicians, purchasers, and policy makers to make informed decisions that improve health care at both the individual and population levels.


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