alexa Comparative Effectıveness of Novokinin, Perindop
ISSN: 2161-1459

Journal of Clinical & Experimental Pharmacology
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Research Article

Comparative Effectıveness of Novokinin, Perindopril and Losartan on Blood Pressure, Adma, Nadph Oxidase and Rho Kinase at Renal Tissue in L-Name and Salt Induced Hypertension

Emre Mutlu1*, Necip Ilhan2, Nevin Ilhan2, Selcuk Ilhan1, Solmaz Susam2 and Engin Sahna1

1Department of Pharmacology, Medical Faculty of Medicine Firat University, Elazig, Turkey

2Department of Biochemistry, Medical Faculty of Firat University, Elazig, Turkey

*Corresponding Author:
Emre Mutlu
Department of Pharmacology
Medical Faculty of Medicine Firat University
Elazig, Turkey
Tel: + 90 424 237 00 00-4635
Fax: + 90 424 237 91 38
E-mail: [email protected]

Received date: August 17, 2015; Accepted date: November 25, 2015; Published date: November 30, 2015

Citation: Mutlu E, Ilhan N, Ilhan N, Ilhan S, Susam S, et al. (2015) Comparative Effectiveness of Novokinin, Perindopril and Losartan on Blood Pressure, Adma, Nadph Oxidase and Rho Kinase at Renal Tissue in L-Name and Salt Induced Hypertension. Clin Exp Pharmacol 5:197. doi: 10.4172/2161-1459.1000197

Copyright: © 2015 Mutlu E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

There is no sufficiently investigation about the effects of novokinin, AT2 receptor agonist, on target molecules associated with organ pathology including ADMA, NADPH oxidase and Rho kinase. In this study we investigated the effects of novokinin, perindopril and losartan on Rho kinase, ADMA, NADPH oxidase at renal tissue blood pressure, in L-NAME and salt induced hypertension. Additionally, a1-adrenergic-induced contraction, ach-induced dilator responses in vessels obtained from hypertensive and pharmacological therapy groups were studied.In this study we investigated the effects of novokinin, perindopril and losartan on blood pressure, Rho kinase, ADMA, NADPH oxidase at renal tissue in L-NAME and salt induced hypertension. Additionally, a1-adrenergic-induced contraction, ach-induced dilator responses in vessels obtained from hypertensive and pharmacological therapy groups were studied. To develop hypertension, L-NAME was administrated intraperitoneally and drinking water with salt (1%) for 4 weeks. Perindopril, losartan, novokinin were administrated intraperitoneally for 2 weeks. Blood pressure was measured by using tail-cuff method; Rho kinase, ADMA and NADPH oxidase were measured by ELÄ°SA at renal tissues.Values are presented as means ± S.E.M.; compared by one way anova. Novokinin, perindopril and losartan diminished the level of NADPH oxidase and ADMA at renal tissue compared to hypertension group. Novokinin, perindopril and losartan decreased blood pressure. The greatest reduction of blood pressure was determined in perindopril treatment group In the hypertensive group, the acetylcholine EC50 value was significantly higher than in the control group and Emax value was significantly lower in hypertensive group compared to control. The application of novokinin, perindopril and losartan were improved the ach induced dilator responses in L-NAME and salt induced hypertension model. AT2 receptor agonist novokinin may offer protection of target organs such as the kidney. In this regard, further experimental studies are needed to exhibit potential benefits of novokinin in hypertension and end organ damage treatment for advanced clinical research.

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