Comparative Evaluation of Enalapril and Losartan in Pharmacological Correction of Experimental Osteoporosis and Fractures of its Background
- *Corresponding Author:
- Faitelson AV
Department of Traumatology and orthopedics and battle field surgery
Kursk State Medical University
305 004, Kursk, Lenina, Russia, 65/22
Tel: 8-(4712) -58-73-14
E-mail: [email protected]
Received Date: Novmber 17, 2011; Accepted Date: April 22, 2012; Published Date: April 24, 2012
Citation: Faitelson AV, Dubrovin GM, Gudyrev OS, Pokrovski MV, Ivanov AV, et al. (2012) Comparative Evaluation of Enalapril and Losartan in Pharmacological Correction of Experimental Osteoporosis and Fractures of its Background. Orthop Muscul Syst 1: 111. doi: 10.4172/2161-0533.1000111
Copyright: © 2012 Faitelson AV, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
In the experiment on the white Wistar female rats (222 animals), the osteoprotective effect of enalapril and losartan was studied on experimental models of osteoporosis and osteoporotic fractures. It was revealed, that in rats after ovariectomy the endothelial dysfunction of microcirculation vessels of osteal tissue develops, resulting in occurrence of osteoporosis and delay of consolidation of experimental fractures. Enalapril and losartan prevented the reduction of microcirculation in bone, which was reflected in slowing the thinning of bone trabecules and in preventing the occurrence of these micro-fractures, as well as increasing quality of experimental fractures healing.