alexa Comparative Evaluation of Oral Transmucosal Fentanyl Citrate and Nasal Transmucosal Midazolam Spray as Premedication in Children | OMICS International | Abstract
ISSN: 2155-6148

Journal of Anesthesia & Clinical Research
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Comparative Evaluation of Oral Transmucosal Fentanyl Citrate and Nasal Transmucosal Midazolam Spray as Premedication in Children

Namrata Paul*

Anaesthesiology & Intensive Care, Shri Guru Ram Rai Medical College, Uttarakhund, India

*Corresponding Author:
Namrata Paul
Anaesthesiology & Intensive Care
Shri Guru Ram Rai Medical College
Uttarakhund, India
Tel: 9557672723
E-mail: [email protected]

Received date: January 07, 2014; Accepted date: January 24, 2014; Published date: January 26, 2014

Citation: Paul N (2014) Comparative Evaluation of Oral Transmucosal Fentanyl Citrate and Nasal Transmucosal Midazolam Spray as Premedication in Children. J Anesth Clin Res 5:379. doi: 10.4172/2155-6148.1000379

Copyright: © 2014 Paul N. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Context: Premedication is an integral part of anaesthetic management. An ideal premedicant drug is anxiolytic, analgesic, sedative and amnestic. It should fulfill the aims of premedication, be safe for the patient and be easily administered.

Aims: To evaluate and compare the efficacy of oral transmucosal fentanyl citrate lollipop and intranasal midazolam spray as a premedication in children by a non-invasive route and to evaluate post-operative sedation score.

Settings and design: Our study was conducted in Government Medical College, Jammu, J&K. It was a comparative clinical trial done in 3 groups (40 subjects in each). The study was approved by the Ethical committee of the Institute.

Methods and material: Children aged 5 to 10 years undergoing surgery in general anaesthesia were included in our study. Informed written consent was obtained from the parents of each child before adding the child in the study.

Statistical analysis used: Data was collected on 120 children. Variables were reported as mean and standard deviation. The difference in mean values across the groups was assessed by One-Way Analysis of Variance (ANOVA). Statistical significance of qualitative variables was assessed with the use of chi-square test. Intergroup comparisons were made post-hoc by Bonferroni’s t-test.

Results: Children who were given oral transmucosal fentanyl citrate (15 μgm/kg) were better sedated in the preoperative period, had less apprehension at venipuncture, had better mask acceptance, were calmer at emergence and post-operative period, as compared to those who were given nasal transmucosal midazolam spray (0.2 mg/kg) or nasal saline spray.

Conclusions: It was concluded that oral transmucosal fentanyl citrate, in the dose of 15 μg/kg, is superior to nasal transmucosal midazolam spray (0.2 mg/kg) in providing preoperative sedation, decreasing anxiety at the time of placement of anaesthesia mask and intravenous cannulation and lowering the level of agitation at emergence.

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A


[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


porn sex

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

Gaziantep Escort

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A


[email protected]

1-702-714-7001Extn: 9037


James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

mp3 indir

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals


Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T


[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version