alexa Comparative Immunomodulatory Activity of Ascaris Suum Eggs and Dermatophagoides pteronyssinus Extract in BALB/C Mice: Cytokine and Immunoglobulin Regulations
ISSN: 2155-6121

Journal of Allergy & Therapy
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Comparative Immunomodulatory Activity of Ascaris Suum Eggs and Dermatophagoides pteronyssinus Extract in BALB/C Mice: Cytokine and Immunoglobulin Regulations

Pineda B Maria Ruth1,2,4* and Ramos, John A Donnie1,3,4

1UST Graduate School, University of Santo Tomas, Manila, Philippines

2Faculty of Pharmacy, University of Santo Tomas, Manila, Philippines

3College of Science, University of Santo Tomas, Manila, Philippines

4Research Cluster for the Natural and Applied Sciences, University of Santo Tomas, Philippines

*Corresponding Author:
Maria Ruth B. 2nd Floor Main Building
Department of Medical Technology
Faculty of Pharmacy
University of Santo Tomas
Manila, Philippines
Tel: (02)-406-1611 local 8398
Fax: (+63)-9064971267
E-mail: [email protected]

Received date: July 19, 2012; Accepted date: August 27, 2012; Published date: August 30, 2012

Citation: Pineda MRB, Ramos JDA (2012) Comparative Immunomodulatory Activity of Ascaris Suum Eggs and Dermatophagoides pteronyssinus Extract in BALB/c Mice: Cytokine and Immunoglobulin Regulations. J Aller Ther 3:119. doi: 10.4172/2155-6121.1000119

Copyright: © 2012 Pineda MRB, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Allergy is highly prevalent in well-developed countries; hygiene hypothesis suggests that this is due to exposure to previous bacterial infection eliciting Th1-response that suppresses Th2-mediated responses. Aside from Th2 suppressing Th1-responses, Th2-mediated infections such as parasitism, appear to lower the risk of developing allergy. This study investigates the effects of Ascaris suum infection in Dermatophagoides pteronyssinus-induced allergic BALB/c mice. Ninety BALB/c mice divided into three trials were randomly grouped into: normal control (1), A. suum infected mice (2), D. pteronyssinus exposed mice (3), A. suum infected mice and then exposed to D. pteronyssinus (4), D. pteronyssinus exposed mice and then infected with A. suum (5), and mice exposed and infected with D. pteronyssinus and A. suum, simultaneously (6). Blood and fecal samples were collected at days 0, 36, and 72 for the measurement of cytokines and immunoglobulins through ELISA, and for fecal analysis.  Results showed that A. suum infection suppressed D. pteronyssinus-induced allergy morphologically  and histologically and downregulated the production of D. pteronyssinus-specific IgE. A. suum and D. pteronyssinus upregulated the production of IL-4 and IL-5, and only A. suum eggs enhanced the production of IL-10. D. pteronyssinus enhanced production of both D. pteronyssinus-specific and A. suum-specific IgE and IgG and may be accounted to crossreacting antigens present in D. pteronyssinus and A. suum. IL-10 is upregulated in mice with A. suum infection and appears to protect mice against D. pteronyssinus-induced allergy. The possible role of IL-10 production in response to A. suum infection and against D. pteronyssinus-induced allergy needs further investigation.


Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version