Comparative Modeling Study of the 3-D Structure of Small Delta Antigen Protein of Hepatitis Delta Virus
- *Corresponding Author:
- Dr. Sarita Singh,
Biotech Park, Sector-G
Uttar Pradesh, India
Tel: +91 522 4053010
Fax: +91 522 4012081
E-mail: [email protected]
Received Date: January 13, 2010; Accepted Date: February 08, 2010; Published Date: February 08, 2010
Citation: Singh S, Gupta SK, Nischal A, Khattri S, Nath R, et al. (2010) Comparative Modeling Study of the 3-D Structure of Small Delta Antigen Protein of Hepatitis Delta Virus. J Comput Sci Syst Biol 3:001-004. doi: 10.4172/jcsb.1000047
Copyright: © 2010 Singh S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Delta hepatitis is pandemic worldwide, which is caused by Hepatitis delta Virus (HDV) an RNA virus. HDV causes either co-infection or super infection with Hepatitis B virus. Small delta antigen protein of HDV is obligatory for replication of virus. Since it plays a crucial role in virus life cycle, it may be a suitable target for drug development. Three dimensional structure of protein is of great significance for the rational design of many different types of biological experiments. In current study 3-D modeling of small delta antigen protein was performed by using GenThreader followed by modeller9v7. The validation of predicted 3-D structure was done using PROCHECK, Anolea, Gromos96 and Swisspdb-viewer tools. CASTp was used further to study surface features and functional binding pockets in protein. The resulting 3-D model can be used to develop novel inhibitor against small delta antigen protein to cure the disease.