alexa
Reach Us +447482877761
Comparative Modeling Study of the 3-D Structure of Small Delta Antigen Protein of Hepatitis Delta Virus | OMICS International | Abstract
ISSN: 0974-7230

Journal of Computer Science & Systems Biology
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Comparative Modeling Study of the 3-D Structure of Small Delta Antigen Protein of Hepatitis Delta Virus

Singh Sarita1,2*, Gupta Sunil Kumar1,2, Nischal Anuradaha2, Khattri Sanjay2, Nath Rajendra2, Seth Prahlad Kishore1 and Pant Kamlesh Kumar2

1Bioinformatics Centre, Biotech Park, Sector-G, Jankipuram, Lucknow-226021, Uttar Pradesh, India

2Department of Pharmacology & Therapeutics, Chhatrapati Shahuji Maharaj Medical University, Chowk, Lucknow-226003, Uttar Pradesh, India

*Corresponding Author:
Dr. Sarita Singh,
Bioinformatics Centre
Biotech Park, Sector-G
Jankipuram, Lucknow-226021
Uttar Pradesh, India
Tel: +91 522 4053010
Fax: +91 522 4012081
E-mail: [email protected]

Received Date: January 13, 2010; Accepted Date: February 08, 2010; Published Date: February 08, 2010

Citation: Singh S, Gupta SK, Nischal A, Khattri S, Nath R, et al. (2010) Comparative Modeling Study of the 3-D Structure of Small Delta Antigen Protein of Hepatitis Delta Virus. J Comput Sci Syst Biol 3:001-004. doi: 10.4172/jcsb.1000047

Copyright: © 2010 Singh S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Delta hepatitis is pandemic worldwide, which is caused by Hepatitis delta Virus (HDV) an RNA virus. HDV causes either co-infection or super infection with Hepatitis B virus. Small delta antigen protein of HDV is obligatory for replication of virus. Since it plays a crucial role in virus life cycle, it may be a suitable target for drug development. Three dimensional structure of protein is of great significance for the rational design of many different types of biological experiments. In current study 3-D modeling of small delta antigen protein was performed by using GenThreader followed by modeller9v7. The validation of predicted 3-D structure was done using PROCHECK, Anolea, Gromos96 and Swisspdb-viewer tools. CASTp was used further to study surface features and functional binding pockets in protein. The resulting 3-D model can be used to develop novel inhibitor against small delta antigen protein to cure the disease.

Keywords

Recommended Conferences

16th World Congress on Structural Biology

Amsterdam, Netherlands
Share This Page
Top