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ISSN: 0975-0851

Journal of Bioequivalence & Bioavailability
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Research Article

Comparative Pharmacokinetic Profile of Aceclofenac from Oral and Transdermal Application

Faiyaz Shakeel1,*, Mohammed S Faisal2 and Sheikh Shafiq3

1Department of Pharmaceutics, Faculty of Pharmacy, Al-Arab Medical University, Benghazi-5341, Libya

2Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi-110062,India

3New Drug Delivery System (NDDS), Zydus Cadila Healthcare Ltd., Ahemdabad, Gujrat, India

*Corresponding Author:
Dr Faiyaz Shakeel
Department of Pharmaceutics
Faculty of Pharmacy
Al-Arab Medical University
Benghazi-5341, Libya
Phone : 00218-913899028
E-mail : [email protected]

Received Date: March 22, 2009; Accepted Date: April 17, 2009; Published Date: April 25, 2009

Citation: Shakeel F, Mohammed SF, Shafiq S (2009) Comparative Pharmacokinetic Profile of Aceclofenac from Oral and Transdermal Application. J Bioequiv Availab 1: 013-017. doi: 10.4172/jbb.1000003

Copyright: © 2009 Shakeel F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The aim of the present investigation was to compare pharmacokinetic profile (bioavailability) of aceclofenac by transdermal and oral application. Nanoemulsion, nanoemulsion gel and marketed tablet (Aceclofar ® ) were subjected to pharmacokinetic (bioavailability) studies on Wistar male rats. Several pharmacokinetic parameters like C max , t max , AUC 0 → t , AUC 0 → α , K e , and T 1/2 were determined for each formulation. The absorption of aceclofenac by transdermally applied nanoemulsion and nanoemulsion gel resulted in 2.95 and 2.60 fold increase in bioavailability as compared to oral tablet formulation. Results of these studies indicated that the nanoemulsions can be successfully used as potential vehicle for enhancement of bioavailability of aceclofenac.

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