alexa Comparative Proteome Analysis of Thalamus and Cortex fr
ISSN: 0974-276X

Journal of Proteomics & Bioinformatics
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Comparative Proteome Analysis of Thalamus and Cortex from Rats Subchronically Treated with Kynurenine and Probenecid

Tran The Thanh, Nguyen Thi Minh Phuong, Nguyen Bich Nhi and Phan Van Chi*

Institute of Biotechnology (IBT), Vietnamese Academy of Science & Technology (VAST), 18 Hoang Quoc Viet, Hanoi, Vietnam

*Corresponding Author:
Dr. Phan Van Chi,
Institute of Biotechnology (IBT)
Vietnamese Academy of Science & Technology (VAST)
18 Hoang Quoc Viet, Hanoi, Vietnam
Tel : (+84-4) 7913657,
E-mail : [email protected]

Received Date: March 12, 2008; Accepted Date: April 10, 2008; Published April 20, 2008

Citation: Tran TT, Nguyen TMP, Nguyen BN, Phan CV (2008). Changes of Serum Glycoproteins in Lung Cancer Patients. J Proteomics Bioinform 1:011-016. doi:10.4172/jpb.1000004

Copyright: © 2008 Tran TT, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Research focusing on glutamate as a major contributor to schizophrenia has attained increasing prominence over the past decade. Analogous to an NMDA-receptor hypofunction in schizophrenia, growing evidence suggest that the disease is related to an excess of brain kynurenic acid (KYNA), an endogenous antagonist at the glycine-site of the NMDA receptor. Previous studies have shown tha t MK-801, an NMDA-receptor antagonist with psychotomimetic properties, induces alteration of several genes and protein levels in cortex and thalamus previously found to be changed in the brains of patients with schizophrenia. In the present study, we use p roteomics to investigate whether an increased KYNA turnover in the brain, induced by subchronic treatment of kynurenine and probenecid, w ould interfere with the protein synthesis in the cortex and thalamus in the rat brain. The levels of four proteins in the cortex wer e increased in the group treated with kynurenine and probenecid compared to vehicle-treated controls. The proteins were; 1, Ubiquitin carbo xy- terminal hydrolase L1 (UCHL1), 2, Similar to NADH dehydrogenase, 3, Cytochrome c oxidase and 4, protein with an undetermined identity. No protein changes were observed in the thalamus. Two of these proteins are implicated in mitochondrial energy produc tions and mRNA from one of them – cytochrome c oxidase – has previously been shown to be increased in the cortex from patients with schizophrenia. Present result show that increased turnover of the endogenous NMDA receptor antagonist KYNA is able to affect cortical protein synthesis to a condition as observed in patients with schizophrenia.


Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version