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Comparative Proteomic Study of Proteins in Prostate Cancer and Benign Hyperplasia Cells | OMICS International | Abstract
ISSN: 1948-5956

Journal of Cancer Science & Therapy
Open Access

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Research Article

Comparative Proteomic Study of Proteins in Prostate Cancer and Benign Hyperplasia Cells

Sergey Shishkin1*, Marina Kovaleva1, Alexei Ivanov1, Lidia Eryomina1, Ksenia Lisitskaya1, Ilia Toropygin2, Leonid Kovalev1, Valeria Okhritz3 and Oleg Loran3

1Laboratory of biomedical research, A.N. Bach Institute of Biochemistry RAS, Moscow, Russia

2Group of Mass-Spectrometry, V.N.Orekhovich Institute of Biomedical Chemistry RAMS, Moscow, Russia

3Urology Department, Russian Medical Academy of Postgraduate Education, Moscow, Russia

*Corresponding Author:
Prof. Sergey S. Shishkin
Laboratory of biomedical research
A.N. Bach Institute of Biochemistry RAS
Moscow, Leninsky pr., 33/2
Moscow, 119071, Russia
Tel: +7 (495) 952-58-89
Fax: +7 (495) 954-270-32
E-mail: [email protected]

Received Date: August 05, 2011; Accepted Date: October 17, 2011; Published Date: October 19, 2011

Citation: Shishkin S, Kovaleva M, Ivanov A, Eryomina L, Lisitskaya K, et al. (2011) Comparative Proteomic Study of Proteins in Prostate Cancer and Benign Hyperplasia Cells. J Cancer Sci Ther S1:003. doi: 10.4172/1948-5956.S1-003

Copyright: © 2011 Shishkin S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Comparative proteomic studies of proteins in DU-145, PC-3, LNCaP and BPH-1 cultivated cells as well as in prostate tissue samples obtained from patients with benign and malignant tumors showed differences in protein profiles, in particular, high content in tissue samples of four isoforms of transgelin and profilin-1. Increased expression of protein Dj-1 was observed in cancer cells and biopsy samples of prostate cancer as opposed to BPH-1 cells and biopsy samples of tissues with benign hyperplasia. Dramatic reduction of serpin H1 was noted in the range of cell lines: BPH-1 → PC-3 → DU-145 → LNCaP. Thus, the obtained data are indicative of protein Dj-1 and serpin H1 participation in formation of the cancer phenotype in prostate cells