alexa Comparative Study for the Analysis of Cefixime Trihydra
ISSN: 2329-6798

Modern Chemistry & Applications
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Research Article

Comparative Study for the Analysis of Cefixime Trihydrate and its Degraded Products by Two RP-HPLC Methods, One its Official and Other Developed Validated Method

Elsadig HK* and Abdalfatah MB

Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Riyadh, Al-kharj, Saudi Arabia

*Corresponding Author:
Elsadig HK
Department of pharmaceutical Chemistry
College of Pharmacy
Prince Sattam Bin Abdulaziz University
Riyadh, Al-kharj, Saudi Arabia
Tel: +966115886094
E-mail: [email protected]

Received Date: February 18, 2017 Accepted Date: February 26, 2017 Published Date:March 03, 2017

Citation: Elsadig HK, Abdalfatah MB (2017) Comparative Study for the Analysis of Cefixime Trihydrate and its Degraded Products by Two RP-HPLC Methods, One its Official and Other Developed Validated Method. Mod Chem Appl 5: 214. doi: 10.4172/2329-6798.1000214

Copyright: © 2017 Elsadig HK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



The aim of the present work was aimed to carry out comparative study between method (1) and method (2) for separation of cefixime trihydrate and its degraded products by using two different mobile phases, keeping the other parameters such as stationary phase, column condition, wavelength, and device. Mobile phase for method (1) consist of a solution of 0.03 M Tetra butyl ammonium hydroxide (pH 6.5) and acetonitrile with a ratio of 3:1 respectively while Mobile phase for method (2) consist of a mixture of 0.1 M sodium dihydrogen phosphate monohydrate solution (pH 2.5) and methanol with a ratio 3:1 respectively. To study the degraded products sample was subjected to Sun light, UV light, and thermal effects. From data obtained proved the method (2) gave less retention time for the separation of drug with a larger number of decomposed products being detected compared by method (1).


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