Comparative Study of Controlled Release Mechanism of Curcumin from different Polymer Matrices
In our previous work we have successfully synthesized chitosan nanocomposites and chitosan hybrid nanocomposites by blending chitosan with other polymers like polyvinyl alcohol (PVA), Polycaprolactone (PCL) and chitosan cross linked derivative by using glutaraldehyde (GLU) ascrosslinker. The nanoclay used for the study was Cloisite 30B.In this research programme we have chosen the best among the each individual polymers(previously synthesized formulationsof polymer) to study the release behaviour of a model anticancer drug curcumin from those polymer/ hybrid polymer nanocomposites. Among chitosan nanocomposites films chitosan dissolved in 2% acetic acid was chosen, similarly CS-PVA (80:20)/ C30B (2.5%) and CS-PCL (80:20)/ C 30B (2.5%), CS cross linked with glutaraldehyde and containing C 30B of 2.5 wt % were chosen for studying the drug release mechanism. Same formulations of drug % were loaded in different polymer matrices and the release pattern was studied in three similar dissolution medium i.e. having pH 4.5, pH 7 and pH 7.5. Their release kinetics were also evaluated by applying various mathematical models proposed by different workers from different parts of the world. And it was concluded that Chitosan- PCL hybrid nanocomposites were proved to be the most suitable matrix for releasing the drug in a controlled manner and for longer duration.