alexa Comparative Study of Different Modified Potentiometric Sensors for Determination of Moxifloxacin HCl in Dosage Forms
ISSN : 2153-2435

Pharmaceutica Analytica Acta
Open Access

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Research Article

Comparative Study of Different Modified Potentiometric Sensors for Determination of Moxifloxacin HCl in Dosage Forms

Gehad G Moamed*, Eman YZ Frag, FA Nour El-Dien and Marwa Saad

Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt

*Corresponding Author:
Gehad G Moamed
Professor of Inorganic and Analytical Chemistry
Chemistry Department, Faculty of Science
Cairo University, Giza, Egypt
Tel: +2 012 9160411
Fax: +202-572556
E-mail: [email protected]

Received Date: April 30, 2015; Accepted Date: July 16, 2015; Published Date: July 20, 2015

Citation: Moamed GG, Frag EYZ, El-Dien FAN, Saad M (2015) Comparative Study of Different Modified Potentiometric Sensors for Determination of Moxifloxacin HCl in Dosage Forms. Pharm Anal Acta 6:397. doi: 10.4172/2153-2435.1000397

Copyright: © 2015 Moamed GG, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

In situ modified carbon paste, screen-printed and PVC electrodes were fabricated for the determination of moxifloxacin hydrochloride (MOXHC). The electrodes under study revealed linear response over wide concentration range of 1.0×10-6 - 1.0×10-2 mol L-1 of MOXHC at 25oC with a monovalent cationic slope. It was found that the slope is 57.2 ± 2.6, 59.2 ± 4.6 and 57.7 ± 2.7 mV decade-1for IPVC electrodes modified with 7.5 mg NaTPB, PMA and PTA ion pairing agents, respectively, and 58.6 ± 1.7, 60.0 ± 2.0 and 59.0 ± 3.3 mV decade-1 for ISPE modified with 22, 16 and 30 mg NaTPB, RN and PTA ion pairing agents, respectively, but 60 ± 2.3 mV decade-1 for ICPE modified with 10 mg NaTPB. Moreover, the selectivity coefficient of the electrodes was determined by applying both matched potential and separate solution methods. The modified SPE sensor shows high selectivity and sensitivity for determination of MOXHC. The response of the electrodes was found to be pH independent in the range of 2-6 for ISPEs and IPVC electrodes and 3-7 for ICPE electrode. The electrodes under study have short response time. This potentiometric method can be used for determination of MOXHC in pharmaceutical preparation and the results obtained agreed with those obtained with HPLC official method. The proposed potentiometric method was validated according to the IUPAC recommendation.

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