alexa Comparative Study of Keratinolytic Activities of Dermatophytes in Various Keratin Substrates | OMICS International | Abstract
ISSN: 2161-0517

Virology & Mycology
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Research Article

Comparative Study of Keratinolytic Activities of Dermatophytes in Various Keratin Substrates

Raheem Ademola RR 1, Omolade Olabowale A1, Folorunso Jamiu B2, Oluwadun A3 and Onilude AA4

1Department of Community Medicine and Primary Care Faculty of Clinical Sciences, Obafemi Awolowo, College of Health Sciences, Olabisi Onabanjo University, Sagamu, Nigeria

2Department of Medical Laboratory Health Services Directorate, Olabisi Onabanjo University, Ago-Iwoye, Nigeria

3Department of Medical Microbiology and Parasitology, Faculty of Basic Medical Sciences, Olabisi Onabanjo University, Sagamu, Nigeria

4 Department of Microbiology, University of Ibadan, Ibadan, Nigeria

*Corresponding Author:
Raheem Ademola RR
Department of Community Medicine and Primary Care Faculty of Clinical Sciences
Obafemi Awolowo
College of Health Sciences
Olabisi Onabanjo University, Sagamu, Nigeria
E-mail: [email protected]

Received date: May 06, 2013; Accepted date: August 08, 2013; Published date: August 12, 2013

Citation: Raheem Ademola RR, Omolade Olabowale A, Folorunso Jamiu B, Oluwadun A, Onilude AA (2013) Comparative Study of Keratinolytic Activities of Dermatophytes in Various Keratin Substrates. Virol Mycol 2:117. doi:10.4172/2161- 0517.1000117

Copyright: © 2013 Raheem Ademola RR, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Objective: Keratinolytic activities of dermatophytes have been a subject of interest to understand the pathogenicity of infection. In this study, we intend to elucidate the keratinase activity profile among the Trichophyton (T), Microsporum (M) and Epidermophyton (E). Methods: 343 clinical isolates of dermatophytesviz; T. mentagrophytes (228), T. rubrum (58), T. shoeleinni (36) M. audouinii (14) and E. floccosum (7) grown on Sabouraud Dextrose broth were inoculated on mineral medium consist of human hair, horse hair, cow hair, chicken feather and fowl scales individually. The keratinolytic activity was measured spectrophotometrically at 660 nm following Folin-Ciocalteu method. Results: The keratinolytic activities of T. mentagrophytes, T. rubrum, T. schoeleinii and M. audouinni of Mean ± SEM viz; 4.89 ± 5.77, 4.51 ± 2.51, 4.57 ± 8.81 and 4.67 + 8.81, respectively were significantly increased in feather except, E. floccosum with an expression of 1.50 ± 2.08 which was significantly low when compared with other keratin P<0.05. There was a significant decrease in keratinolytic activities of all the dermatophytes in fowl scales P<0.05. Conclusion: We concluded that the pathogenicity potential of dermatophytes depends on its keratinolytic activities and the structure of the keratin material.


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