alexa Comparative Study of the Influence of Iem-1556 and Glatiramer Acetate (Copaxon) on the Severity of Neurologic Disorders and the Duration of Experimental Allergic Encephalomielitis in the Rats| Abstract
ISSN: 2376-0389

Journal of Multiple Sclerosis
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  • Research Article   
  • J Mult Scler,
  • DOI: 10.4172/2376-0389.1000217

Comparative Study of the Influence of Iem-1556 and Glatiramer Acetate (Copaxon) on the Severity of Neurologic Disorders and the Duration of Experimental Allergic Encephalomielitis in the Rats

Abdurasulova IN, Matsulevich AV, Serdyuk SE and Gmiro VE*
Institute for Experimental Medicine, , Saint Petersburg, Russia
*Corresponding Author : Gmiro VE, Institute for Experimental Medicine, Saint Petersburg, Russia, Tel: 7-812-911-174-57-68, Email: [email protected]

Received Date: Dec 20, 2017 / Accepted Date: Jan 29, 2018 / Published Date: Feb 05, 2018

Abstract

The effect of N-decyltropine chloride (IEM-1556) and the reference drug glatiramer acetate (GA) on the severity of neurological disorders and the duration of the experimental allergic encephalomyelitis (EAE), modeling the processes of neural inflammation, demyelination and neurodegeneration characteristic for multiple sclerosis were studied. EAE in female Wistar rats was induced by a single subcutaneous (SC) inoculation of the homologous spinal cord homogenate in complete Freund’s adjuvant. The test preparations were administered from 2 to 16 days after induction of EAE. The severity of the disease was assessed in scores (from 0 to 6) by the presence in animals of persistent paresis and paralysis. The course systemic administration of IEM-1556 in a dose of 3 mg/kg reduced the severity and duration of EAE in rats, comparable to GA. Advantage of IEM-1556 before GA is the possibility of non-invasive application, as well as the presence of analgesic, antiparkinsonian and antidepressant action. It is assumed that the therapeutic effect of IEM-1556 is related to its ability to release endogenous adenosine, which causes neuroprotective, analgesic, antiparkinsonian and antidepressant effects of the drug.

Keywords: Multiple sclerosis; EAE; Adenosine; IEM-1556; Copaxone

Citation: Abdurasulova IN, Matsulevich AV, Serdyuk SE, Gmiro VE (2018) Comparative Study of the Influence of Iem-1556 and Glatiramer Acetate (Copaxon) on the Severity of Neurologic Disorders and the Duration of Experimental Allergic Encephalomielitis in the Rats. J Mult Scler (Foster City) 5: 217. Doi: 10.4172/2376-0389.1000217

Copyright: ©2018 Abdurasulova IN, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

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