alexa Comparison of Acid-base Status and Hemodynamic Stability during Propofol and Sevoflurane-based Anesthesia in Patients Undergoing One Lung Ventilation | OMICS International| Abstract
ISSN: 2161-0444

Medicinal Chemistry
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  • Research Article   
  • Med Chem (Los Angeles) 2019, Vol 9(5): 60

Comparison of Acid-base Status and Hemodynamic Stability during Propofol and Sevoflurane-based Anesthesia in Patients Undergoing One Lung Ventilation

Rui Yang1#, Zhi-Xin Gao1#, Dan Zhao1 and Guang-Hong Xu1,2*
1Department of Anesthesiology, First Affiliated Hospital, Anhui Medical University, 218 Jixi Road, Hefei, Anhui 230022, China
2Department of Neurology, First Affiliated Hospital, Anhui Medical University, 218 Jixi Road, Hefei, Anhui 230022, China
#Contributed equally to this work
*Corresponding Author : Guang-Hong Xu, Department of Anesthesiology, First Affiliated Hospital, Anhui Medical University, 218 Jixi Road, Hefei, Anhui 230022, China, Tel: +86055162922344, Email: [email protected]

Received Date: May 21, 2019 / Accepted Date: Jun 03, 2019 / Published Date: Jun 10, 2019

Abstract

Background: This study compared the effects of Propofol and Sevoflurane anesthesia on the stabilization of acid-base values and hemodynamic parameters during one lung ventilation (OLV).

Methods: Patients with OLV were randomized two groups: the Propofol group (Group P, n=23) and the Sevoflurane group (Group S, n=23). In Group P, patients were induced and maintained with Propofol. In Group S, patients were induced with Propofol and maintained with Sevoflurane. Blood samples were obtained one minute before OLV (t1) and 1, 2 hours (t2, t3) after OLV. Hemodynamic values were recorded at patients entered operation room (T1); one minute before intubation (T2); 1, 3, and 5 minutes after intubation (T3, T4, T5); one minute before OLV (T6); and 1, 2 hours after OLV (T7, T8).

Results: There were significant differences between different time points in pH value, base excess, and bicarbonate (P<0.001). The values of pH, base excess and bicarbonate in two groups both tended to reduce progressively from t1 to t3. There were no significant differences between the groups at all of the time points. There were significant differences between the different time points in terms of mean arterial pressure and heart rate (P<0.001), more patients in Group P received Nicardipine for hypertension (P<0.001). However, there were no significant intergroup differences.

Conclusions: The duration of one lung ventilation, anesthesia and operation, rather than the anaesthetic used, are key factors in maintaining acid-base balance during OLV. Sevoflurane anesthesia is superior to Propofol anesthesia in avoiding the fluctuation of hemodynamic parameters.

Keywords: Acid-base; Hemodynamic; Propofol; Sevoflurane; One lung ventilation

Citation: Yang R, Gao ZX, Zhao D, Xu GH (2019) Comparison of Acid-base Status and Hemodynamic Stability during Propofol and Sevoflurane-based Anesthesia in Patients Undergoing One Lung Ventilation. Med Chem (Los Angeles) 9: 060-064.

Copyright: © 2019 Yang R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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