alexa Comparison of Active Ingredient Consistency of Some Brand and Generically Available Glucosamine Products in Iranian Pharmacies | OMICS International | Abstract
ISSN: 2165-8048

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Research Article

Comparison of Active Ingredient Consistency of Some Brand and Generically Available Glucosamine Products in Iranian Pharmacies

Ali BZ* and Mina-sadat K

Department of Pharmacology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Corresponding Author:
Ali BZ
Department of Pharmacology
Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Tel: +98 913 351 6057
E-mail: [email protected]

Received Date: October 09, 2016; Accepted Date: November 30 2016; Published Date: December 14, 2016

Citation: Ali BZ, Mina-sadat K (2016) Comparison of Active Ingredient Consistency of Some Brand and Generically Available Glucosamine Products in Iranian Pharmacies. Intern Med 6:226. doi:10.4172/2165-8048.1000226

Copyright: © 2016 Ali BZ, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Glucosamine is used by patients with osteoarthritis and rheumatoid arthritis. Wide variety of simple or complex Glucosamine products are offered with great different prices in Iranian pharmacies. Glucosamine is a small molecule therefore its absorption and bioavailability after oral administration is nearly complete and irrelevant to its formulation. The aim of this report is to consider Glucosamine content of such products and have a comparison to discuss if generics are as effective as brand ones.
A total of 15 products containing Glucosamine were assessed to measure Glucosamine content, at first derivatization was performed by adding phenylisothiocyanate. Then phenylthiourea derivative of Glucosamine was determined by spectrophotometer at 240 nm. To ensure non-interference of other substances, Glucosamine content of complex products also were determined with high-performance liquid chromatography (HPLC), C18 column and mobile phase phosphate buffer/acetonitrile (90/10 1 ml/min) with UV detector at 240 nm.
Glucosamine compared with amount had been mentioned in label was ranging from 93.22% to 125.14%. Almost 85% of products had active ingredient more than amount claimed on label. Comparison of HPLC analysis with spectrophotometric data indicated acceptable selectivity of spectrophotometric method for Glucosamine determination in two sample products and those containing Glucosamine plus other active ingredients such as chondroitin and methylsulfonylmethane (MSM).
One way analysis of variance (ANOVA) performed for comparison of means achieved after several Glucosamine determinations in one brand. In the basis of our study and appropriate bioavailability of Glucosamine, generic products of that also would be acceptable despite lower prices.

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