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Comparison Of Immunonephelometric And Immunoturbidimetric Methods for Measuring Beta 2-Microglobulin: Fit for Purpose in Routine Clinical Laboratories | Abstract
ISSN: 2161-1009

Biochemistry & Analytical Biochemistry
Open Access

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Research Article

Comparison Of Immunonephelometric And Immunoturbidimetric Methods for Measuring Beta 2-Microglobulin: Fit for Purpose in Routine Clinical Laboratories

Ozlem Goruroglu Ozturk1,2*, Sedefgul Yuzbasioglu Ariyurek1, Filiz Kibar1, Esin Damla Ziyanoglu Karacor2, Gulhan Sahin2, Gulay Sezgin3 and Akgun Yaman1

1Cukurova University, Balcali Hospital, Central Laboratory, Adana, Turkey

2Cukurova University, Faculty of Medicine, Department of Clinical Biochemistry, Adana, Turkey

3Cukurova University, Faculty of Medicine, Department of Pediatric Hematology and Oncology, Adana, Turkey

*Corresponding Author:
Ozlem Goruroglu Ozturk
Medical Biochemistry, Cukurova Universitesi
Cukurova University, A.D. 01330 Adana, Turkey
Tel: +905062642268
Fax: +903223386943
E-mail: [email protected]

Received Date: September 20, 2012; Accepted Date: October 04, 2012; Published Date: October 08, 2012

Citation: Ozturk OG, Ariyurek SY, Kibar F, Karacor EDZ, Sahin G, et al. (2012) Comparison Of Immunonephelometric And Immunoturbidimetric Methods for Measuring Beta 2-Microglobulin: Fit for Purpose in Routine Clinical Laboratories. Biochem Anal Biochem 1:119. doi: 10.4172/2161-1009.1000119

Copyright: © 2012 Ozturk OG, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Serum free beta 2-microglobulin (b2M) level has been regarded as an independent biomarker in several cancers, and has traditionally been analyzed using methods such as Immunonephelometry on specialized analyzers. It is now possible to perform this test on clinical chemistry analyzers, using immunoturbidimetry. The aim of this study was to compare these two methods, for measuring serum b2M level. Fourty three samples which were randomly chosen from sera of patients with various malignant conditions were analyzed for serum b2M level, both by immunonephelometric method in Beckman Immage 800 (Beckman Coulter Inc., CA, USA) nephelometer, and by immunoturbidimetric method in Beckman UniCel DXC 800 Synchron (Beckman Coulter Inc., CA, USA) auto-analyzer. Method comparison demonstrated good agreement between the immunonephelometric and immunoturbidimetric b2M testing, in which we found good correlation (r=0.973) and high accuracy (slope=1.009). As a conclusion, Beckman UniCel DXC 800 Synchron immunoturbidimetric b2M assay is suitable for routine use, and correlates well with representative immunonephelometric assays on the Beckman Immage 800 analyzer. The ability to perform specific protein analyses such as b2M on an integrated clinical chemistry/immunoassay system, can allow consolidation of testing on a single platform and results in improved laboratory operations efficiency. It is thought that immunoturbidimetric method can be used safely in the routine screening of serum b2M level, for different types of malignancies


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