alexa Comparison of Macrodosimetric Efficacy of Transarterial
ISSN: 2090-0902

Journal of Physical Mathematics
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Comparison of Macrodosimetric Efficacy of Transarterial Radioembolization (TARE) by Using 90Y Microspheres of Different Density of Activity

Traino AC1*, Piccinno M1, Boni G2, Bargellini I3 and Bozzi E3

1Unit of Medical Physics, University Hospital Pisana, Italy

2Unit of Nuclear Medicine, University Hospital Pisana, Italy

3S.D Radiologia Vascular and Interventional, University Hospital Pisana, Italy

*Corresponding Author:
Traino AC
Professor, Unit of Medical Physics
University Hospital Pisana, Italy
Tel: +39 050992957
E-mail: [email protected]

Received Date: July 01, 2015; Accepted Date: January 11, 2016; Published Date: January 15, 2016

Citation: Traino AC, Piccinno M, Boni G, Bargellini I, Bozzi E (2016) Comparison of Macrodosimetric Efficacy of Transarterial Radioembolization (TARE) by Using 90Y Microspheres of Different Density of Activity. J Phys Math 7:150. doi:10.4172/2090-0902.1000150

Copyright: © 2016 Traino AC, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Purpose: Transarterial 90Y microspheres radioembolization is emerging as a multidisciplinary promising therapeutic modality for primary and metastatic cancer in the liver. Actually two different type of microspheres are used, whose main characteristic is the different density of activity (activity per microsphere). In this paper the effect due to the possible different distribution of the microspheres in a target is presented and discussed from a macrodosimetric point of view. Material and methods: A 100 g virtual soft-tissue target region has been builded. The administered activity was chosen to have a target average absorbed dose of 100 Gy and the number of 90Y microspheres needed was calculated for two different activity-per-microsphere values (2500) Bq/microsphere and 50 Bq/microsphere, respectively). The spheres were randomly distributed in the target and the Dose Volume Histograms were obtained for both. The cells surviving fractions (SF) for four different values of the radiobiological parameter α were calculated from the Linear - Quadratic model. Results: The DVH obtained are very similar and the SF is almost equal for both the activity-per- microsphere values. Conclusions: This macrodosimetric approach shows no radiobiological difference between the glass and resin microspheres. Thus the different number of microspheres seems to have no effect when the number of spheres is big enough that the distance between the spheres in the target can be considered small compared to the range of the β-particles of 90Y.


Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version