alexa Comparison of Nifedipine and Bed Rest for Inhibiting Threatened Preterm Labour
ISSN: 2161-0932

Gynecology & Obstetrics
Open Access

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Research Article

Comparison of Nifedipine and Bed Rest for Inhibiting Threatened Preterm Labour

Saifon Chawanpaiboon* and Sujin Kanokpongsakdi

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand 10700

*Corresponding Author:
Saifon Chawanpaiboon
Division of Maternal-Fetal Medicine
Department of Obstetrics and Gynecology
Faculty of Medicine, Siriraj Hospital
Mahidol University, Bangkok, Thailand 10700
Tel: 66-2-419-4777
Fax: 66-2-418-2662
E-mail: [email protected]

Received date: August 01, 2012; Accepted date: September 12, 2012; Published date: September 21, 2012

Citation: Chawanpaiboon S, Kanokpongsakdi S (2012) Comparison of Nifedipine and Bed Rest for Inhibiting Threatened Preterm Labour. Gynecol Obstet 2:131. doi:10.4172/2161-0932.1000131

Copyright: © 2012 Chawanpaiboon S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Objective: To compare the success rate of nifedipine administration as a tocolytic agent and bed rest for preventing uterine contraction of pregnant women with threatened preterm labour. Methods: A total of 188 pregnant women with threatened preterm labour between 26-35 weeks were enrolled in this study. Cervical measurement was performed in all patients. All women in each group (94 cases) were randomly inhibited uterine contraction with nifedipine administration and bed rest intervention. Results: Nifedipine took the shorter time than bed rest for contraction inhibition in threatened preterm labour with statistical significance. (nifedipine: 2.31 ± 1.19 hours, bed rest: 2.54 ± 0.71 hours) From subgroup analysis, the success rate of nifedipine inhibition and bed rest in the patients with cervical length <3 cm were 83.9% (26 cases) and 55.2% (16 cases), respectively, which was different with statistical significance. Conclusions: Nifedipine can be used successfully to inhibit contractions in threatened preterm labour. However, if the cervical length was ≥ 3 cm, bed rest should be firstly applied to avoid unnecessary medical intervention.


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