Anesthesia & Clinical Research
Open Access

Abstract

Comparison of the Effects of Colloid Preload and Ephedrine Bolus Administration on Left Ventricular Loading and Quality of Spinal Anesthesia

Onur Özlü, Süreyya Aydin, Ebru Salman A, Mustafa Aksoy and Mustafa Çağatay

Background: We aimed to investigate the effects of colloid preload or ephedrine bolus on ventricular wall stress by measuring plasma N terminal-Brain natriuretic peptide (NT-ProBNP) concentrations in patients undergoing arthroscopic knee surgery under spinal anesthesia. Methods: 60 patients ASA I-II, aged 20-60 were randomly assigned into two groups. Spinal anesthesia was induced with 0.5% 3 ml levobupivacaine. In Group K (n=30) patients received 500 ml of HES (130/0.4) solution 20 minutes prior to spinal anesthesia. In Group E (n=30) ephedrine 15 mg i.v was injected 1 minute after spinal anesthesia. SBP, DBP, MBP, HR were recorded before and 3,5,7,10,15,20,25,30,45,60,120,240 min. after spinal anesthesia spinal anesthesia and in both groups and in group K also recorded before preload. The plasma concentrations of NT-ProBNP were measured before and 1 and 3 hours after the spinal block.