Comparison of the Effects of Colloid Preload and Ephedrine Bolus Administration on Left Ventricular Loading and Quality of Spinal Anesthesia
- *Corresponding Author:
- Ebru Salman A
Atatürk Research and Trainning Hospital, Ankara, Turkey
E-mail: [email protected]
Received date: September 17, 2012; Accepted date: October 09, 2012; Published date: October 27, 2012
Citation: Özlü O, Aydin S, Ebru Salman A, Aksoy M, Çagatay M (2012) Comparison of the Effects of Colloid Preload and Ephedrine Bolus Administration on Left Ventricular Loading and Quality of Spinal Anesthesia. J Anesth Clin Res 3:247. doi: 10.4172/2155-6148.1000247
Copyright: © 2012 Özlü O, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: We aimed to investigate the effects of colloid preload or ephedrine bolus on ventricular wall stress by measuring plasma N terminal-Brain natriuretic peptide (NT-ProBNP) concentrations in patients undergoing arthroscopic knee surgery under spinal anesthesia.
Methods: 60 patients ASA I-II, aged 20-60 were randomly assigned into two groups. Spinal anesthesia was induced with 0.5% 3 ml levobupivacaine. In Group K (n=30) patients received 500 ml of HES (130/0.4) solution 20 minutes prior to spinal anesthesia. In Group E (n=30) ephedrine 15 mg i.v was injected 1 minute after spinal anesthesia. SBP, DBP, MBP, HR were recorded before and 3,5,7,10,15,20,25,30,45,60,120,240 min. after spinal anesthesia spinal anesthesia and in both groups and in group K also recorded before preload. The plasma concentrations of NT-ProBNP were measured before and 1 and 3 hours after the spinal block.
Results: Mean both groups were similar with respect to MBP. In Group K, NT-proBNP concentrations were significantly higher at the first and third hours of spinal block than baseline values (p=0,003, p<0,001). Mean NTproBNP concentrations were similar between the groups.
Conclusion: Colloid preload with 500 ml and ephedrine 15 mg i.v injection could be used for hypotension prophylaxis during spinal anesthesia with hemodynamic stability.