alexa Comparison of the Macro-circulatory Effects of the New Generation Plasma Expander EAF-HexaPEGylated Albumin (EAF-PEG-BSA) in a Rabbit Hemorrhagic Shock Model: a Comparison with Conventional Crystalloid and Colloid Solutions | Abstract
ISSN: 2155-6148

Journal of Anesthesia & Clinical Research
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Research Article

Comparison of the Macro-circulatory Effects of the New Generation Plasma Expander EAF-HexaPEGylated Albumin (EAF-PEG-BSA) in a Rabbit Hemorrhagic Shock Model: a Comparison with Conventional Crystalloid and Colloid Solutions

P L To2 , R A Gunther2 , J S Jahr1 *, R J Holtby1 , B Driessen3 , S A Acharya4 , P C Chen5 and A T W Cheung2

1Department of Anesthesiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA

2Departments of Surgery and Pathology and Laboratory Medicine, UC Davis School of Medicine, Davis, CA, USA

3Department of Clinical Sciences, New Bolton Center, University of Pennsylvania School of Veterinary Medicine, Kennett Square, PA, USA

4Department of Physiology and Biophysics and Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA

5Department of Bioengineering, School of Engineering, University of California San Diego, La Jolla, CA, USA

*Corresponding Author:
JS Jahr, M.D
Department of Anesthesiology
David Geffen School of Medicine at UCLA
Ronald Reagan UCLA Medical Center, 757 Westwood Plaza
Suite 3325, Los Angeles, CA90095, USA
E-mail: [email protected]

Received Date: July 10, 2013; Accepted Date: August 22, 2013; Published Date: August 24, 2013

Citation: To PL, Gunther RA, Jahr JS, Holtby RJ, Driessen B, et al. (2013) Comparison of the Macro-circulatory Effects of the New Generation Plasma Expander EAF-HexaPEGylated Albumin (EAF-PEG-BSA) in a Rabbit Hemorrhagic Shock Model: a Comparison with Conventional Crystalloid and Colloid Solutions. J Anesthe Clinic Res 4:343.doi: 10.4172/2155-6148.1000343

Copyright: © 2013 To PL, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Introduction: HexaPEGylated albumin (PEG-BSA) is a new class of low viscosity Nitric Oxide (NO) producing active plasma expander.The macro-circulatory response to PEG-BSA of a 4 gm solution of PEG-BSA was studied in a rabbit hemorrhagic shock and resuscitation model and compared that of 0.9% sodium chloride and albumin 25%.

Methods: Five New Zealand white rabbits were anesthetized utilizing ketamine with diazepam and propofol. Endotracheal intubation was performed, animals were ventilated, and anesthesia maintained with isoflurane and diazepam. Following placement of vascular lines for measuring physiological variables, 45 minutes were allowed for equilibration prior to collecting baseline values laboratory and physiologic values. Animals were bled over 30 min to reach a Mean Arterial Pressure (MAP) of 30-41 mmHg .This pressure was maintained for an additional 30 min. Post-Hemorrhage (PH) values were recorded one hour after initiation.

Results: The hematocrit decreased by hemorrhagic shock, and the Heart Rate (HR) returned to the baseline in all 25% PEG-BSA rabbits and in 75% PEG-BSA, HR was greater than baseline. In the saline group, MAP and SvO2 returned to baseline values, the restitution of the baseline value was least effective with albumin, while with PEG albumin the values returned to near control values. Cardiac Output (CO) did not return to the baseline values when resuscitated with saline or 25% albumin, but returned close to the baseline with PEG-BSA both with the 25% and exceeding the baseline value in the 75% group. The pH returned to baseline in all rabbits, whereas lactate increased, remaining elevated relative to the baseline.

Conclusion: The responses to the resuscitation by the three fluids in rabbit hemorrhagic chock models are distinct. Resuscitation with 0.9% sodium chloride, improves only MAP and SvO2 suggesting improved responses. The PEG-BSA as well as albumin, improved MAP, SvO2, HR, pH, and lactate, but PEG-BSA at lower levels compared to albumin.

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