alexa Comparison of the Therapeutic Effects of Rectal Diclofenac Sodium and Intramuscular Pethidine Injection in the Treatment of Acute Renal Colic: A Randomized Clinical Trail | Abstract
ISSN: 2167-0870

Journal of Clinical Trials
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Research Article

Comparison of the Therapeutic Effects of Rectal Diclofenac Sodium and Intramuscular Pethidine Injection in the Treatment of Acute Renal Colic: A Randomized Clinical Trail

Mohammad Mehdi Hosseini1*, AlirezaYousefi2, Leila Ghahramani3 , Mohsen Rastegari1 and Abdoul-Rasoul Ebrahimi2
1Nephrology-Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
2Urology Department, Jahrom University of Medical Sciences, Jahrom, Iran
3Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Corresponding Author : Mohammad Mehdi Hosseini, MD
Urology Office, Faghihi Hospital
Zand Blvd.,Shiraz, Iran
Tel: +98-71-32331006
Fax: +98-71-32330724
E-mail: [email protected]
Received March 28, 2015; Accepted May 18, 2015; Published May 20, 2015
Citation: Hosseini MM, Yousefi A, Ghahramani L, Rastegari M, Ebrahimi AR (2015) Comparison of the Therapeutic Effects of Rectal Diclofenac Sodium and Intramuscular Pethidine Injection in the Treatment of Acute Renal Colic: A Randomized Clinical Trail. J Clin Trials 5:225. doi:10.4172/2167-0870.1000225
Copyright: © 2015 Hosseini MM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Objectives: Renal colic is a type of abdominal pain commonly caused by obstructive stones. The aim of this study was to compare the safety and efficacy of rectal diclofenac sodium (RDS) and intramuscular pethidine (IMP) injection in acute renal colic.

Materials and Methods: In an interventional prospective double-blind randomized clinical trial, 541 patients who had referred to our center because of acute renal colic were divided into two groups: (1) RDS with 266 participants and (2) IMP with 275 participants. Pain relief was measured by asking the participants at 10, 20 and 30 minutes after taking each drug.

Results: In RDS group, analgesic effects of RDS were apparent in 121 participants (45.5%) after 10 min, in 191 participants (71.9%) after 20 min and in 233 participants (87.5%) after 30 min. 33 participants (12.5%) had no response to RDS. In IMP group, analgesic effects of IMP were apparent in 123 participants (44.7%) after 10 min, in 191 participants (69.5%) after 20 min and in 254 participants (92.3%) after 30 min. 21 participants (7.7%) had no response to IMP. Statistical analysis revealed that there was no significant difference between the two studied drugs in relieving renal colic pain (P=0.06).

Conclusion: Although there was no significant difference in analgesic effect between the two drugs, using diclofenac sodium in suppository form is highly recommended for renal colic patients because of availability, being less expensive, safety, and its self-administration.

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