alexa Comparison Study of Clinical Presentation and Surgical Outcome between Children and Adults with Craniopharyngioma: A 22-Year Single-Center Experience in Southern Taiwan
ISSN: 2329-6895

Journal of Neurological Disorders
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Research Article

Comparison Study of Clinical Presentation and Surgical Outcome between Children and Adults with Craniopharyngioma: A 22-Year Single-Center Experience in Southern Taiwan

Cheng-Wei Chu1, Yu-Feng Su2,3, Ann-Shung Lieu2,3, Chih-Lung Lin2,3, Aij-Lie Kwan2,3 and Joon-Khim Loh1,2,3*

1Department of Surgery, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan

2Division of Neurosurgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan

3Faculty of Medicine, Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

*Corresponding Author:
Joon-Khim Loh
Department of Surgery
Kaohsiung Municipal Ta-Tung Hospital
Kaohsiung Medical University
Kaohsiung, Taiwan
Tel: 886-7-2911101-8926
Fax: 886-7-2138405
E-mail: [email protected]

Received date: June 05, 2017; Accepted date: June 18, 2017; Published date: June 21, 2017

Citation: Chu C, Su Y, Lieu A, Lin C, Kwan A, et al. (2017) Comparison Study of Clinical Presentation and Surgical Outcome between Children and Adults with Craniopharyngioma: A 22-Year Single-Center Experience in Southern Taiwan. J Neurol Disord 5: 350. doi:10.4172/2329-6895.1000350

Copyright: © 2017 Chu C, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Background: The differences in clinical presentation and surgical outcome between children and adults with craniopharyngioma have not been well-described and there are few data available for Asian population. The aim of this study is to investigate the differences between paediatric and adult patients with craniopharyngioma at a single medical centre in southern Taiwan.

Methods: The clinical records of 40 patients with craniopharyngioma who were all surgically treated at Kaohsiung Medical University Hospital from January 1990 to December 2012 were reviewed. The patients were divided into two groups based on age: children (= 20 years) and adults (>20 years). MRI and CT images were obtained pre- and post-operatively. Histopathological examination diagnosed tumors. Statistical analyses were performed to compare the differences in the two groups.

Results: Among the patients, 17 were children and 23 were adults. The children group demonstrated more diagnoses of large or giant tumors (p<0.001), a higher rate of tumors with both solid and cystic composition (p=0.027) as well as adamantinomatous type tumors (p=0.020). The children group also had a higher surgical complication rate of diabetes insipidus (p=0.023).

Conclusions: There are significant differences between children and adults with craniopharyngioma with regard to tumor size, histopathology type of tumor and hormone-related surgical complications. These findings are useful for improving the strategies for managing patients with craniopharyngioma.


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