alexa Complete Remission of Multicentric Castleman’s Disease developed in a HIV+ Patient after the Start of HAART
ISSN 2155-6113

Journal of AIDS & Clinical Research
Open Access

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Case Report

Complete Remission of Multicentric Castleman’s Disease developed in a HIV+ Patient after the Start of HAART

Alessandro Perretti1, Valentina Zuccaro1, Antonello Malfitano1, Giuseppe Barbaro2 and Giorgio Barbarini1

1Infectious Diseases Department, IRCCS Policlinico San Matteo Foundation, University of Pavia, Viale Taramelli, 5 Pavia, Italy

2Department of Experimental Medicine, Section, of Medical Pathophysiology, University La Sapienza, Rome, Italy

*Corresponding Author:
Giorgio Barbarini
IRCCS Policlinico San Matteo Foundation
Infectious Diseases Department
University of Pavia, Italy
Tel: 39-368249624
E-mail: [email protected]

Received date: May 24, 2014; Accepted date: July 30, 2014; Published date: August 12, 2014

Citation: Perretti A, Zuccaro V, Malfitano A, Barbaro G, Barbarini G (2014) Complete Remission of Multicentric Castleman’s Disease developed in a HIV+ Patient after the Start of HAART. J AIDS Clin Res 5:337. doi:10.4172/2155-6113.1000337

Copyright: © 2014 Perretti A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



In August 2010, we diagnosed a Multicentric Castleman’s Disease (MCD) in a HIV+ patient with generalized lymphadenopathy, splenomegaly and pericardial effusion. A few days before the onset of symptoms, the patient had started anti-retroviral therapy with Abacavir/Lamivudine (ABC/3TC) +Ritonavir-boosted Atazanavir (ATV/r). During the hospitalization he developed a severe pancytopenia with liver failure, and he started immediately the Therapy with steroids, Ganciclovir, and Rituximab. At the 46 months follow-up, the patient is asymptomatic, his biochemical values are essentially normal with a complete regression of the superficial and deep lymphadenopathies.


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