Complete Remission of Multicentric CastlemanÃ¢ÂÂs Disease developed in a HIV+ Patient after the Start of HAART
- *Corresponding Author:
- Giorgio Barbarini
IRCCS Policlinico San Matteo Foundation
Infectious Diseases Department
University of Pavia, Italy
E-mail: [email protected]
Received date: May 24, 2014; Accepted date: July 30, 2014; Published date: August 12, 2014
Citation: Perretti A, Zuccaro V, Malfitano A, Barbaro G, Barbarini G (2014) Complete Remission of Multicentric Castleman’s Disease developed in a HIV+ Patient after the Start of HAART. J AIDS Clin Res 5:337. doi:10.4172/2155-6113.1000337
Copyright: © 2014 Perretti A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
In August 2010, we diagnosed a Multicentric Castleman’s Disease (MCD) in a HIV+ patient with generalized lymphadenopathy, splenomegaly and pericardial effusion. A few days before the onset of symptoms, the patient had started anti-retroviral therapy with Abacavir/Lamivudine (ABC/3TC) +Ritonavir-boosted Atazanavir (ATV/r). During the hospitalization he developed a severe pancytopenia with liver failure, and he started immediately the Therapy with steroids, Ganciclovir, and Rituximab. At the 46 months follow-up, the patient is asymptomatic, his biochemical values are essentially normal with a complete regression of the superficial and deep lymphadenopathies.