alexa Complete Response of Hepatocellular Carcinoma to Sorafenib: A Case Report and Review of Literatures
ISSN: 2167-0889

Journal of Liver
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Case Report

Complete Response of Hepatocellular Carcinoma to Sorafenib: A Case Report and Review of Literatures

Lian-yu Chen1,2, Kun Wang1,2 and Zhen Chen1,2*
1Department of Integratived Oncology, Fudan University Shanghai Cancer Center, China
2Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China
Corresponding Author : Zhen Chen
Department of integrative oncology
Fudan University Shanghai Cancer Center
270 Dong An Road, Shanghai, China
Tel: 86-021-64175590-82605
E-mail: [email protected]
Received August 05, 2014; Accepted August 28, 2014; Published September 08, 2014
Citation: Chen LY, Wang K, Chen Z (2014) Complete Response of Hepatocellular Carcinoma to Sorafenib: A Case Report and Review of Literatures. J Liver 3:164. doi: 10.4172/2167-0889.1000164
Copyright: © 2014 Chen LY, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Background: Sorafenib is the current standard treatment for advanced and unresectable hepatocellular carcinoma (HCC). Although the efficacy of sorafenib on the overall survival and time to progression has been repeatedly proven, clinically evident and sustainable response especially Complete Response (CR) is rarely observed after its treatment. Case Report: We report a case of a 64-year old female patient with unresectable HCC who received sorafenib treatment of more than 8 months following a Transarterial Chemoembolization (TACE) treatment. The patient had a rapid and complete response within 1 month of sorafenib treatment, which sustained for more than 7 months after the initiation of the therapy. Conclusions: This result suggests that sorafenib alone or its use with TACE may be useful in the treatment of unresectable HCC. Translational clinical trials are needed to identify and exploit the underlying mechanism for this superb but rare observation.

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