alexa Complete Response to Systemic Combination Therapy in a Gastric Cancer Patient in Inoperable Condition: A Case Report
ISSN: 2165-7920

Journal of Clinical Case Reports
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Case Report

Complete Response to Systemic Combination Therapy in a Gastric Cancer Patient in Inoperable Condition: A Case Report

Kenneth Alibek1,2*, Igor Ponomarev2, Bauyrzhan Aituov1, Ainur Kakpenova1, Assel Mussabekova1 and Bolat Sultankulov1
1Nazarbayev University, 53 Kabanbay Batyr Avenue, Astana, 010000, Kazakhstan
2Republican Scientific Center for Emergency Care, 3 Kerey and Zhanibek Khanov Street, Astana, 010000, Kazakhstan
Corresponding Author : Kenneth Alibek
Nazarbayev University
53 Kabanbay Batyr Avenue
Astana, 010000, Kazakhstan
E-mail: [email protected]
Received July 24, 2012; Accepted August 25, 2012; Published August 27, 2012
Citation: Alibek K, Ponomarev I, Aituov B, Kakpenova A, Mussabekova A, et al. (2012) Complete Response to Systemic Combination Therapy in a Gastric Cancer Patient in Inoperable Condition: A Case Report. J Clin Case Rep 2:188. doi:10.4172/2165-7920.1000188
Copyright: © 2012 Alibek K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: Gastric cancer is a leading cause of death worldwide and the average survival rate of patients within a year of diagnosis remains low. Currently, surgical resection is the major treatment strategy, and the effectiveness of chemotherapy remains debatable. Infections involving Helicobacter pylori (H. pylori) and the Epstein-Barr virus have been implicated in gastric cancer pathogenesis. In addition, extensive immunosuppression in patients caused by latent infections and chemotherapy limits their response to existing therapies. Case presentation: A 73-year-old man presented with stage IV gastric cancer (T2N0MII stage, cell group II). The tumor was inoperable due to concomitant multiorgan dysfunction and consequently, the patient was treated with a combinatorial therapy consisting of immunocorrective and antimicrobial therapy, as well as chemotherapy. The medications used for treatment include interferon-α, interleukin-2, statins, fenofibrate, macrolides, proton pumps, and antiviral drugs. Following treatment, tumor cells redifferentiated into normal glandular epithelial cells. A 2-year followup study of the patient after treatment revealed a complete remission from cancer. Conclusion: This case report demonstrates the possibility of using a systemic approach to treat inoperable gastric cancer. In addition, the observations made in this study should aid the design of novel treatment strategies for gastric cancer.

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