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ISSN: 2153-0769

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Completing the Metabolome

Peter L. Elkin1*, Mark S. Tuttle1 and Steven H. Brown2,3

1Center for Biomedical Informatics, Mount Sinai School of Medicine, New York, NY, USA

2Department of Medicine, Vanderbilt University, TN, USA

3Department of Veterans Affairs, Vanderbilt University, TN, USA

*Corresponding Author:
Peter L. Elkin, M.D., MACP, FACMI
Center for Biomedical Informatics
Mount Sinai School of Medicine, New York, USA
Tel: 212- 860-3837
Fax: 212-824-2329
E-mail: [email protected]

Received date: June 29, 2012; Accepted date: July 03, 2012; Published date: July 05, 2012

Citation: Elkin PL, Tuttle MS, Brown SH (2012) Completing the Metabolome. Metabolomics 2:e115. doi: 10.4172/2153-0769.1000e115

Copyright: © 2012 Elkin PL, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


At the turn of the millennium, genomics was in full swing as scientists world-wide worked to sequence the human genome. During this time period, we were already aware that the sequenced genome did not tell the entire story. Scientists had begun to discuss functional genomics and metabolomics [1,2]. Of course we have long been aware of metabolic pathways. We have researched and taught pathways such as the Krebs Cycle for generations. In 1996 the Kyoto Encyclopedia of Genes [3] and Genomics (KEGG) published version 1.0 of their online compendium of pathways. KEGG has grown to approximately 165 metabolic pathways (Figure 1) out of a total of 425 metabolic, regulatory and signaling pathways [4]. Despite this progress, many researchers suspect that known pathways may not be completely understood and that additional metabolic pathways have yet to be discovered.

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