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Complications after Cardiac Surgery due to Allogeneic Blood Transfusions | OMICS International | Abstract
ISSN: 2155-9880

Journal of Clinical & Experimental Cardiology
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Review Article

Complications after Cardiac Surgery due to Allogeneic Blood Transfusions

YM Bilgin1*, LMG van de Watering2
1Department of Hematology, Erasmus MC, Rotterdam-the Netherlands
2Sanquin - LUMC Center for Clinical Transfusion Research, Leiden-the Netherlands
Corresponding Author : YM Bilgin
Department of Hematology, PO Box 5201
3008 AE Rotterdam-the Netherlands
Tel: 0031-10-7041367
Fax: 0031-10-7041004
E-mail: [email protected]
Received April 07, 2013; Accepted June 23, 2013; Published June 25, 2013
Citation: Bilgin YM, van de Watering LMG (2013) Complications after Cardiac Surgery due to Allogeneic Blood Transfusions. J Clin Exp Cardiolog S7:005. doi: 10.4172/2155-9880.S7-005
Copyright: © 2013 Bilgin YM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Cardiac surgery is worldwide a common procedure, which requires large numbers of red blood cells. Allogeneic blood transfusions are necessary for correction of anemia and bleeding disorders, although blood transfusions are associated with higher morbidity and mortality. Possible complications of blood transfusions contributing to increased risk for morbidity and mortality are transfusion-transmitted infections, transfusion-related acute lung injury (TRALI), and storage of blood products related complications and due to transfusion-related immunomodulation (TRIM). Probably complications due to TRIM are the most common cause of transfusion-related mortality after cardiac surgery. A possible cause for complications due to TRIM is that allogeneic blood transfusions given during cardiac surgery can aggravate a pre-existent inflammatory response after cardiac surgery. In this review we focus on these causes of complications of blood transfusions in cardiac surgery.

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