alexa Complications of Type 1 Diabetes Mellitus are Associated with Renin Angiotensin System: The Role of Physical Exercise as Therapeutic Tool | OMICS International
ISSN: 2165-7092

Pancreatic Disorders & Therapy
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Review Article

Complications of Type 1 Diabetes Mellitus are Associated with Renin Angiotensin System: The Role of Physical Exercise as Therapeutic Tool

Fiorino P1 and Evangelista FS2*
1Renal, Cardiovascular and Metabolic Physiopharmacology Laboratory, Health and Biological Science Center, Mackenzie University, Brazil
2School of Arts, Science and Humanities, University of Sao Paulo, Brazil
Corresponding Author : Fabiana S. Evangelista
School of Arts, Science and Humanities, Sao Paulo University
Av. Arlindo Bettio, Ermelino Mattarazzo-São Paulo-SP,CEP Brazil
Tel: 55113091-8855
E-mail: [email protected]
Received April 08, 2014; Accepted June 03, 2014; Published June 05, 2014
Citation: Fiorino P, Evangelista FS (2014) Complications of Type 1 Diabetes Mellitus are Associated with Renin Angiotensin System: The Role of Physical Exercise as Therapeutic Tool. Pancreat Disord Ther 4:133. doi:10.4172/2165-7092.1000133
Copyright: 2014 Fiorino P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Type 1 diabetes mellitus (T1DM) is associated with the development of severe complications including
cardiovascular diseases, nephropathy, retinopathy and neuropathy. The peptide Angiotensin II (Ang II), the main
effector molecule of the renin angiotensin system (RAS), has been widely investigated because it plays an important
role in the pathogenesis of T1DM and evidence in the literature suggests the pharmacological blockade of the RAS
components as a potential therapeutic strategy to minimize the deleterious effects of T1DM by improving
metabolism control, renal and cardiovascular functions.Physical exercise can also contribute to avoid the
complications of T1DM by enhancing metabolism of carbohydrates and lipids, peak oxygen consumption, vascular
function, autonomic response and arterial blood pressure. Furthermore, the physical exercise is able to reduce the
level of tissue RAS. Thus, part of the benefits of physical exercise for prevention and treatment of metabolic and
cardiovascular diseases in T1DM may be mediated by the RAS. The present review aimed to discuss the evidence
regarding the involvement of the RAS in the progression of T1DM, the relevance of physical exercise to the
management of T1DM and the role of physical exercise to induce adaptations in the RAS. 

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