alexa Composite MET-PET Fusion 3.0 Tesla MRI is a New Sensitive Method for the Detection of GH Secreting Adenomas with Abnormal GH Secretary Dynamics
ISSN: 2167-0943

Journal of Metabolic Syndrome
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Research Article

Composite MET-PET Fusion 3.0 Tesla MRI is a New Sensitive Method for the Detection of GH Secreting Adenomas with Abnormal GH Secretary Dynamics

Shunsuke Satoh1, Hidetoshi Ikeda1*, Toshiyuki Saginoya2 and Kazuo Watanabe3
1Reseach Institute for Pituitary Disease, Southern Tohoku General Hospital, Koriyama, Fukushima 963-8563, Japan
2Department of Radiology, Southern Tohoku General Hospital, Koriyama, Fukushima 963-8563, Japan
3Reseach Institute for Neuroscience, Southern Tohoku General Hospital, Koriyama, Fukushima 963-8563, Japan
Corresponding Author : Hidetoshi Ikeda
Research Institute for Pituitary Disease
Southern Tohoku Research Institute for Neuroscience
7-115 Yatsuyamada, Koriyama
Fukushima 963-8563, Japan
Tel: +81-24-934-5322
Fax: +81-24-922-5320
E-mail: [email protected]
Received September 21, 2012; Accepted November 25, 2012; Published November 29, 2012
Citation: Satoh S, Ikeda H, Saginoya T, Watanabe K (2012) Composite MET-PET Fusion 3.0 Tesla MRI is a New Sensitive Method for the Detection of GH Secreting Adenomas with Abnormal GH Secretary Dynamics. J Metabolic Synd S2:005. doi:10.4172/2167-0943.S2-005
Copyright: © 2012 Satoh S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Objective: To evaluate the usefulness of methionine (MET)-Positron Emission Tomography (PET) for the early diagnosis of Growth Hormone (GH) secreting adenomas, we retrospectively analyzed patients with abnormal GH dynamics and a histologically confirmed GH secreting pituitary adenoma who underwent pre-operative fluorodeoxyglucose-/MET-PET.

Materials and methods: Thirty-two patients with abnormal GH dynamics were included in this study. 3 Tesla (3T) -MRI, [18F]-flurodeoxyglucose (FDG) -/[11C]-MET-PET, and transsphenoidal surgery were performed in all the patients. We determined correlations among FDG-/MET-PET (maximum standardized uptake value (SUVmax)), serum GH and IGF-1 levels, the GH response to a 75 g Oral Glucose Tolerance Test (OGTT), Thyrotropin-Releasing Hormone (TRH) /Luteinizing Hormone-Releasing Hormone (LHRH) loading tests, tumor volume, and proliferative activity.

Results: The diagnostic sensitivity for early GH secreting adenoma was highest for MET-PET (100%), followed by TRH/LHRH (80%), 75 g OGTT (67%), and FDG-PET (47%). Significant correlations were observed between: MET-PET SUVmax and FDG-PET SUVmax (p<0.01), MET-/FDG-PET SUVmax and tumor volume (MET: p<0.01; FDG: p<0.01) ; MET-/FDG PET SUVmax and MIB-1 labeling index (MET: p<0.01; FDG: p=0.01) ; GH/insulin-like growth factor (IGF)-1 levels and tumor volume (GH: p=0.01; IGF-1: p<0.01) ; and GH and IGF-1 levels (p<0.01).

Conclusions: All the patients with abnormal GH dynamics detected by MET-PET had GH adenomas, indicating that MET-PET is useful for the early diagnosis of GH adenomas.

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