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Computational Analysis of Ultra-Structural Images of Red Blood Cells | OMICS International | Abstract
ISSN: 2476-2261

Journal of Oncology Translational Research
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Research Article

Computational Analysis of Ultra-Structural Images of Red Blood Cells

Madhumita Das1,2, Bishwajit Das1,2, Avishek Das1,3, Ishita Chatterjee1,4 and Durjoy Majumder1,2*

1Society for Systems Biology and Translational Research, Bangur Avenue, Kolkata, India

2Department of Physiology, West Bengal State University, Barasat, Kolkata, India

3Department of Information Technology, Adamas Institute of Technology, Barasat, Kolkata, India

4Department of Applied Psychology, University of Calcutta, Rajabazar Campus, Kolkata, India

*Corresponding Author:
Durjoy Majumder
Department of Physiology, West Bengal State University
Berunanpukuria, Malikapur, Barasat, Kolkata 700 126 or
Society for Systems Biology & Translational Research
103, Block – C, Bangur Avenue, Kolkata 700 055, India
Tel: 033 2524 1979
E-mail: [email protected], [email protected]

Received date: September 29, 2015; Accepted date: December 06, 2015; Published date: December 13, 2015

Citation: Das M, Das B, Das A, Chatterjee I, Majumder D (2015) Computational Analysis of Ultra-Structural Images of Red Blood Cells. Oncol Trans Res 1:104. doi:10.4172/jotr.1000104

Copyright: © 2015 Das M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Light microscopic images are routinely used in clinical diagnosis. Further the confirmation of disease diagnosis is relied with the ultra-structural images. Scanning electron microscopy (SEM) with high resolution and high magnification is granted as one of the reliable process in this aspect. However, pathologists’ criteria for a disease diagnosis for both the processes are on the basis of qualitative and empirical in nature. In a number of hematological diseases as well as in different pathological conditions like liver cirrhosis morphological alteration of red blood cell alteration is reported. Recently some morphological alteration in red blood cells (RBC) by ultra-structural analysis has been reported in leukemic patients, though leukemia is a disease of white blood cells. It is expected that these features could be used as an event of cancer cachexia or can be used as the identifying marker for pre-cancer state. However, a systematic study so far is not done in terms of proper quantitative statement. Here an attempt has been made towards the development of an automated image analysis procedure for extracting quantitative information from the scanning electron microscopic (SEM) images. This computational approach may guide the clinicians to take a decision about the disease/pre-disease state with a quantitative outlook.


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